Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Palanisamy, Sathyadevi; Vijayaraghavan, Priya; Wang, Yen-Yun; Yao, Yi-Wen; Huang, Bo-Cheng; Chen, Wen-Liang; Kao, Chai-Lin; Yuan, Shyng-Shiou F.; Wang, Yun-Ming Title A name given to the resource Exploring boronate-appended hyperbranched amino-functionalized dendrimer-empowered sensors for the potential recognition of FSH in age-categorized human plasma samples Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Applied Materials Today;Volume;48;Issue;;Article No.;103006; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.apmt.2025.103006" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.apmt.2025.103006</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105023144334?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105023144334?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Palanisamy S., Department of Chemistry, National Taiwan Normal University, Taipei, 11677, Taiwan, Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, B), National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan; Vijayaraghavan P., Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, B), National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, Department of Chemistry, CHRIST University, Karnataka, Bengaluru, 560029, India; Wang Y.-Y., College of Dental Medicine, School of Dentistry, Kaohsiung Medical University, Kaohsiung, 807, Taiwan, Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan; Yao Y.-W., Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, 807, Taiwan; Huang B.-C., Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, 807, Taiwan; Chen W.-L., Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, B), National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan; Kao C.-L., Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, 807, Taiwan; Yuan S.-S.F., Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan, Faculty and College of Medicine, Translational Research Center and Department of Obstetrics and Gynecology, Kaohsiung Medical University, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan; Wang Y.-M., Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, B), National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, Center for Neurotechnology and Assistive Technology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan Description An account of the resource Boronic acids can act as ideal saccharide receptors as they possess a high affinity for diols and readily form cyclic-boronate esters when reacting in an aqueous medium. Here, we present hydrophilic amino-functionalized boronic acid dendrimer (Af-BAD) for the first time, with significantly enhanced sensitivity towards Follicle Stimulating Hormone (FSH) detection. In this study, newly synthesized Af-BAD was dip-coated on a gold substrate to create an impedance-type sensing working electrode. The effects of Af-BAD coating on the gold chip, the sensing properties for FSH recognition, sensitivity, and stability were measured by the charge transfer resistance across the electrochemical setup. The impedimetric measurements were conducted in the presence of [Fe(CN)6]3-/[Fe(CN)6]4- redox reporter at pH 7.4. The increments in the charge-transfer resistance were monitored upon increasing the FSH concentrations from 25 fg/mL to 100 pg/mL. The device achieved good sensitivity with a calculated detection limit of 4.01 fg/mL and acceptable linearity. The observed behavior was linear concerning the tested concentrations. An attempt at a real application to serum samples was also successfully conducted. Meanwhile, the level of tolerance of boronic acid dendrimer with other competing glycoproteins and monosaccharides was also tested. In this study, we also compared human plasma FSH levels in female oral cancer patients and normal controls using the Af-BAD modified device and the clinically used ELISA method. With a sound understanding of boronate materials and their affinity, amino functionalized multi-boronic acid dendrimer was developed as a highly selective conjugate toward glycoprotein FSH detection. Copyright 2025. Published by Elsevier Ltd. Subject The topic of the resource Biosensor; Clinical sample; Dendrimer; Electrochemistry; Gold chip Publisher An entity responsible for making the resource available Elsevier Ltd Relation A related resource ISSN: 23529407; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online