Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Chen, Xiao-Qi; Vijayaraghavan, Priya; Palanisamy, Sathyadevi; Amer, Tarik Abdelkareem Mostafa; Lu, Tsai-Te; Chen, Chiao-Yun; Wang, Yun-Ming Title A name given to the resource Stepwise hydrothermally synthesized gold nanoparticles supported copper metal-organic frameworks as an impedimetric immunosensor for the ultrasensitive detection of pancreatic cancer Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Electrochimica Acta;Volume;542;Issue;;Article No.;147524; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.electacta.2025.147524" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.electacta.2025.147524</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105019300825?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105019300825?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Chen X.-Q., Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan; Vijayaraghavan P., Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Department of Chemistry, Christ University, Hosur Road, Bengaluru, 560029, India; Palanisamy S., Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan; Amer T.A.M., Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan; Lu T.-T., Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan, Department of Chemistry, National Tsing Hua University, Hsinchu, 30013, Taiwan, Department of Chemistry, Chung Yuan Christian University, Taoyuan, 32023, Taiwan; Chen C.-Y., Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan, School of Post-Baccalaureate Medicine, College of Medicine, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, 807, Taiwan; Wang Y.-M., Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, Department of Biomedical Science and Environmental Biology, School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan Description An account of the resource Carbohydrate antigen (CA199) is a frequently used biomarker for detecting and prognosis of pancreatic cancer. Early detection of pancreatic cancer remains a challenge in routine clinical analyses, including imaging techniques such as magnetic resonance imaging, ultrasonography, and computed tomography. There is an urgent urge to develop robust sensors like electrochemical immunosensors that provide low-priced and sensitive biomarker detection. A potential electrochemical immunosensor comprising Au nanoparticles supported on Cu MOF, HKUST-1 (Au@HKUST-1) on screen-printed carbon electrodes (SPCE) was developed via a one-pot stepwise hydrothermal method for the ultralow level detection of CA 199 in human serum using electrochemical impedance spectroscopy (EIS). CA 199 could be detected in a wide range of concentrations, including 0.01 U mL-1 to 35 U mL-1. Au@HKUST-1/SPCE sensor displayed ultralow levels of detection of CA 199 with a limit of detection (LOD) in PBS as 0.17 U mL-1 and serum as 0.08 U mL-1. The limit of quantification of the immunosensor is 0.53 U mL-1 and 0.26 U mL-1 in PBS and serum, respectively. This work also emphasizes the ultrasensitive detection of pancreatic cancer using CA 199 biomarker in serum samples, and achieved a reliable analytical platform for the detection of CA 199 and other biomarkers. 2025 Elsevier Ltd. Subject The topic of the resource Au nanoparticles; Electrochemical sensor; Human serum; Metal-organic frameworks; Pancreatic cancer Publisher An entity responsible for making the resource available Elsevier Ltd Relation A related resource ISSN: 134686; CODEN: ELCAA Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online