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Creator An entity primarily responsible for making the resource Joy, Jean Mary; P?, Amruth; Paul, Preethy Treesa; M?, Rosemol Jacob; Dara, Pavan Kumar; Mathew, Suseela Title A name given to the resource Innovative fish peptide-loaded chitosomes: Advancing bioactive delivery through comprehensive in vitro and in vivo assessments Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Food Chemistry Advances;Volume;7;Issue;;Article No.;100947; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.focha.2025.100947" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.focha.2025.100947</a> <br /><br /><a href="https://www.scopus.com/pages/publications/86000464051?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/86000464051?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Joy J.M., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Faculty of Marine Sciences, Cochin University of Science and Technology, Kerala, Cochin, 682022, India, Department of Zoology, St. Teresa's College (Autonomous), Kerala, Ernakulam, 682011, India; P? A., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Faculty of Marine Sciences, Cochin University of Science and Technology, Kerala, Cochin, 682022, India, Department of Life Sciences, Christ University, Hosur Main Road, Bhavani Nagar, Karnataka, Banglore, 560029, India; Paul P.T., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Faculty of Marine Sciences, Cochin University of Science and Technology, Kerala, Cochin, 682022, India; M? R.J., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Faculty of Marine Sciences, Cochin University of Science and Technology, Kerala, Cochin, 682022, India; Dara P.K., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Department of Biotechnology, Faculty of Science and Humanities, SRMIST, Tamil Nadu, Kattankulathur, 603203, India; Mathew S., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India Description An account of the resource Considerable advancements have been achieved in controlled delivery systems, yet ensuring optimal stability, bioavailability, and precise targeting of bioactive compounds continues to present challenges. Addressing this gap, the present study explores chitosomeslipid vesicles stabilized by chitosanas a promising approach to enhance the delivery efficiency of bioactive molecules. This study investigate fish peptide-loaded chitosomes, leveraging chitosan's biocompatibility, biodegradability, and encapsulation capabilities. A comprehensive evaluation was conducted under both in vitro and in vivo conditions to assess their potential applications. In vitro studies using L929 cell lines demonstrated high biocompatibility, efficient cellular uptake, and sustained cell viability, with a dose-dependent cytotoxicity profile, leading to early and late apoptosis. The tolerance, favourable metabolic stability, and biomarker responses were validated by in vivo evaluations in Albino Wistar rats, demonstrating systemic efficacy and safety. Moreover, the peptide-chitosome formulation demonstrated a lipid-lowering impact, as evidenced by increases in high-density lipoprotein (HDL) and unsaturated fatty acids and decreases in triglycerides, saturated fatty acid content, and low-density lipoprotein (LDL). These findings highlight the potential of fish peptide-loaded chitosomes as an advanced bioactive delivery system, addressing existing limitations and expanding their applicability in nutraceutical and therapeutic formulations. 2025 The Author(s) Subject The topic of the resource Chitosome; Fish bioactive peptide; Nutraceuticals; Stability Publisher An entity responsible for making the resource available Elsevier Ltd Relation A related resource ISSN: 2772753X; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Format The file format, physical medium, or dimensions of the resource online