Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Felicia Aswathy Waliaveettil; Anila, E.I. Title A name given to the resource Chitosan stabilized platinum nanoparticles: In vitro and in vivo screening for analgesic and anti-inflammatory applications Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived International Journal of Biological Macromolecules;Volume;307;Issue;;Article No.;142103; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.ijbiomac.2025.142103" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.ijbiomac.2025.142103</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105000123776?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105000123776?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Felicia Aswathy Waliaveettil, Department of Physics and Electronics, CHRIST University, Karnataka, Bengaluru, 560029, India; Anila E.I., Department of Physics and Electronics, CHRIST University, Karnataka, Bengaluru, 560029, India Description An account of the resource In this interdisciplinary research work, the chitosan stabilized platinum nanoparticles are synthesized through the wet chemical method, and the structural, surface morphological, and optical characterizations are done using X-ray crystallography, Raman spectroscopy, transmission electron microscopy, etc. The samples were tested in in vitro trials namely egg albumin denaturation assay and DPPH radical scavenging assays and showed significantly lower effective concentrations (EC50) such as 5.44 ?g/ml and 8.068 ?g/ml respectively. The in vitro experiments were followed by in vivo animal model for analgesic and anti-inflammatory behaviour at two doses of 25 mg/kg and 50 mg/kg utilizing the hot plate method and the carrageenan-induced paw edema model respectively. The in vivo hot plate model for analgesic effect demonstrated that the chitosan stabilized platinum nanoparticles perform exceptionally well and show &gt;90 % analgesia (p &lt; 0.01) by extending the reaction time in the hot plate methodindicating better analgesia. Carrageenan-induced paw edema model demonstrated the exceptional anti-inflammatory ability of chitosan-stabilized platinum nanoparticles. Despite being given at a comparatively lower dosage, chitosan stabilized platinum nanoparticles showed a considerable decrease in paw volume (4045 % edema inhibition) by the third hour of the anti-inflammatory experimentation (p &lt; 0.01) outperforming the standard drug aspirin given at 100 mg/kg. 2025 Elsevier B.V. Subject The topic of the resource Analgesic property; Anti-inflammatory property; Chitosan; DPPH assay; In vivo animal studies; Platinum nanoparticle Publisher An entity responsible for making the resource available Elsevier B.V. Relation A related resource ISSN: 1418130; CODEN: IJBMD Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online