Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Thomas, Nebu George; Gomes, Fernando; Balakrishnan, Raneesh; Raju, Rani Shine; Ninan, Neethu; Rajan, Anju; Bright, Richard; Anil, Sukumaran; Le, Thien Ngoc; Luu, Trong Quan; Thangadurai, T. Daniel; Bincy, P.K.; Thomas, Sabu Title A name given to the resource Engineered core-shell nanocomposite fibres incorporating bio-ceramics and bioactive molecules for wound repair Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived International Journal of Pharmaceutics;Volume;690;Issue;;Article No.;126533; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.ijpharm.2025.126533" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.ijpharm.2025.126533</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105027194407?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105027194407?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Thomas N.G., Pushpagiri Institute of Medical Sciences and Research Centre, Pushpagiri Medical Society, Kerala, Tiruvalla, 689101, India, Pushpagiri College of Dental Sciences, Medicity, Kerala, Tiruvalla, India, Universidade Federal do Rio de Janeiro (UFRJ), RJ, Rio de Janeiro, Brazil; Gomes F., Universidade Federal do Rio de Janeiro (UFRJ), RJ, Rio de Janeiro, Brazil, College of Engineering &amp; Computing, Florida International University, Miami, FL, United States; Balakrishnan R., Department of Physics, Catholicate College, Kerala, Pathanamthitta, 689645, India; Raju R.S., Pushpagiri Institute of Medical Sciences and Research Centre, Pushpagiri Medical Society, Kerala, Tiruvalla, 689101, India, Department of Chemistry and Centre for Research and Development, KPR Institute of Engineering and Technology, Tamil Nadu, Coimbatore, 641407, India; Ninan N., Pushpagiri Institute of Medical Sciences and Research Centre, Pushpagiri Medical Society, Kerala, Tiruvalla, 689101, India, College of Medicine and Public Health, Flinders University, Bedford Park, 5042, SA, Australia; Rajan A., Department of Physics, Catholicate College, Kerala, Pathanamthitta, 689645, India; Bright R., College of Medicine and Public Health, Flinders University, Bedford Park, 5042, SA, Australia; Anil S., Department of Dentistry, Oral Health Institute, Hamad Medical Corporation, Doha, Qatar; Le T.N., College of Medicine and Public Health, Flinders University, Bedford Park, 5042, SA, Australia; Luu T.Q., College of Medicine and Public Health, Flinders University, Bedford Park, 5042, SA, Australia; Thangadurai T.D., Department of Chemistry and Centre for Research and Development, KPR Institute of Engineering and Technology, Tamil Nadu, Coimbatore, 641407, India; Bincy P.K., ICAR - Central Institute of Fisheries Technology, Matsyapuri, Willington Island, Cochin, 682 029, India; Thomas S., International and Inter University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kerala, Kottayam, India, CHRIST University (Central Campus), Karnataka, Bangalore, India, Trivandrum Engineering Science &amp; Technology (TrEST) Research Park, Kerala, Thiruvananthapuram, India Description An account of the resource Skin plays a major role in protecting the body from external injuries and contaminants. Despite the self-healing mechanisms of the body, wound healing has several limitations, such as being time-consuming, leading to scar formation, and susceptibility to infections. In this study, a novel coreshell nanofibre membrane was designed to protect wounds and prevent secondary trauma, thereby enhancing the wound healing process. A coreshell nanofibre membrane was prepared using polycaprolactone (PCL) as the core polymer loaded with astaxanthin (ASTX) and bioglass (BG), while the shell was made from polylactic acid (PLA) containing nanohydroxyapatite (nHA) to support faster wound healing. The surface structure, morphology, and hydrophilicity of the fibres were extensively characterised. The analysis revealed uniform, well-organised, interconnected coreshell nanocomposite fibres ideal for cell adhesion and growth. In vitro studies have demonstrated enhanced cell viability and wound closure in mouse L929 fibroblast cells. Immune response studies on test membranes loaded with ASTX, BG, and nHA revealed strong anti-inflammatory and antibacterial activities against Gram-positive and Gram-negative bacteria. In vivo studies indicated favourable cellular responses and superior wound healing potential of membranes incorporated with ASTX, BG and a higher concentration of nHA. These findings highlight the potential of coreshell nanofibre membranes as an innovative wound dressing for full-thickness skin injuries, showing significant promise for biomedical applications, especially in wound healing treatments. 2025 Subject The topic of the resource Astaxanthin; Bioactive molecules; Bioceramics; Bioglass; Core-shell nanofibres; Electrospinning; Fish scalederived nHA; Wound healing Publisher An entity responsible for making the resource available Elsevier B.V. Relation A related resource ISSN: 3785173; CODEN: IJPHD Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online