ItemArticle

Green synthesis of Fe-doped manganese oxide nanoparticles: enhanced their antibacterial and anticancer properties assessed by biological analysis

Title
Green synthesis of Fe-doped manganese oxide nanoparticles: enhanced their antibacterial and anticancer properties assessed by biological analysis
Creator
Dharmaraj, Praveenkumar; Ramesh, Sivalingam; Kakani, Vijay; Kim, Heung Soo; Arulselvan, Palanisamy; Ramalingam, Thenmozhi; Indumathi, T.
Description
Eco-friendly synthesis methods are becoming increasingly important as a sustainable way to produce nanoparticles, thereby improving their potential for biomedical applications. The nanoparticles have a small size, a high surface area-to-volume ratio, and the ability to be functionalized with targeting ligands, making them ideal for drug delivery, imaging, and diagnostic purposes. In anticancer therapies, nanoparticles can enhance treatment efficacy by improving drug solubility, enabling controlled release, and selectively targeting cancer cells, thereby minimizing side effects on healthy cells. In the present work, the green engineering of manganese oxide (GEMn2O3) and iron-doped manganese oxide (GEFe@Mn2O3) nanoparticles (NPs) was achieved using a green process with Cynoglossum zeylanicum extract. The synthesized nanoparticles were characterized by XRD, FTIR, DLS, PL, and FESEM analysis. The antibacterial activity of GEMn?O? and GEFe@Mn?O? NPs was tested against S. aureus. GEFe@Mn?O?NPs showed significant antibacterial activity as compared to the GEMn?O?NPs. The antioxidant activity of GEMn?O? and GEFe@Mn?O? NPs was studied again using the DPPH assay. Cytotoxicity assays demonstrated that GEMn?O? and GEFe@Mn?O? NPs exhibit significant anticancer activity against a human blood cancer cell line (MOLT-4). The findings indicate a strong correlation between the increased oxygen vacancies of the GEFe@Mn?O? NPs and their enhanced biocidal properties. This suggests that GEFe@Mn?O? nanoparticles (NPs) are promising candidates for antibacterial and anticancer applications due to their unique physicochemical properties, including enhanced redox activity, reactive oxygen species (ROS) generation, and potential for targeted cellular interaction. The incorporation of iron (Fe) and manganese oxide (Mn?O?) provides synergistic effects that can disrupt microbial cell membranes and induce apoptosis in cancer cells through oxidative stress. Moreover, the engineered nanostructure of GEFe@Mn?O? NPs may offer improved biocompatibility and the ability to penetrate biological barriers, making them suitable for therapeutic delivery and biomedical interventions. 2025 Elsevier B.V.
Source
Inorganic Chemistry Communications;Volume;183;Issue;;Article No.;115897;
Date
01-01-2026
Publisher
Elsevier B.V.
Subject
Antibacterial; Anticancer activity; Green synthesis; iron doping; Manganese oxide
Coverage
Dharmaraj P., KIRND Institute of Research and Development PVT LTD, Tamil Nadu, Tiruchirappalli, India; Ramesh S., Department of Mechanical, Robotics and Energy Engineering, Dongguk University-Seoul, Pil-dong, Jung-gu, Seoul, 04620, South Korea; Kakani V., Department of Integrated System Engineering, Inha University, 100 Inha-ro, Nam-gu, Incheon, 22212, South Korea; Kim H.S., Department of Mechanical, Robotics and Energy Engineering, Dongguk University-Seoul, Pil-dong, Jung-gu, Seoul, 04620, South Korea; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Tamil Nadu, Chennai, 602105, India, Department of Biochemistry, Karpagam Academy of Higher Education (Deemed to be University), Tamil Nadu, Coimbatore, 641 021, India; Ramalingam T., Department of Microbiology, Shrimati Indira Gandhi College, Tamil Nadu, Tiruchirappalli, India; Indumathi T., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 13877003; CODEN: ICCOF
Format
online
Language
English
Type
Article

Citation

Dharmaraj, Praveenkumar; Ramesh, Sivalingam; Kakani, Vijay; Kim, Heung Soo; Arulselvan, Palanisamy; Ramalingam, Thenmozhi; Indumathi, T., “Green synthesis of Fe-doped manganese oxide nanoparticles: enhanced their antibacterial and anticancer properties assessed by biological analysis,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22316.

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