Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Thangavelu, Indumathi; Tadepalli, Srinivas Title A name given to the resource Biocompatible NiTiO3Dopamine nanocomposites for combating drug-resistant pathogens through membrane disruption and oxidative stress Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Journal of Drug Delivery Science and Technology;Volume;114;Issue;;Article No.;107553; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.jddst.2025.107553" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.jddst.2025.107553</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105018614208?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105018614208?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia Description An account of the resource The rising threat of multidrug-resistant pathogens poses a challenge to public health. Highlighting the urgent need for novel antimicrobial agents, this study reports the synthesis of NiTiO3 nanoparticles and dopamine-functionalized NiTiO3 nanocomposites. Structural and elemental confirmation was obtained through XPS studies, which confirmed the presence of Ni2+ and Ti4+ in the nanocomposite, along with C 1s and O 1s peaks corresponding to dopamine coating. Photoluminescence spectra revealed that the NiTiO3dopamine nanocomposite exhibits notable green emission bands at 510, 518, and 527nm which arises from deep-level recombination associated with complex oxygen-related defects like oxygen vacancies. The NiTiO3-dopamine exhibited enhanced antimicrobial activity against S. aureus, B. subtilis, K. pneumoniae, S. dysenteriae, and C. albicans, compared to NiTiO3 alone. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays further revealed that NiTiO3dopamine achieved MIC at 600?g/mL and MBC at 1000?g/mL for K. pneumoniae, outperforming pure NiTiO3. ROS assays confirmed oxidative stress-mediated antimicrobial action, with ROS levels significantly quenched in the presence of histidine. SEM images of bacterial morphology showed extensive membrane disruption in NiTiO3dopamine treated cells. Furthermore, zebrafish embryo assays confirmed excellent biocompatibility of the NiTiO3dopamine nanocomposite, with normal development observed up to 72h post fertilization. 2025 Published by Elsevier B.V. Subject The topic of the resource Antimicrobial activity; Biocompatibility assay; NiTiO₃dopamine nanocomposite; ROS; Zebra fish Publisher An entity responsible for making the resource available Editions de Sante Relation A related resource ISSN: 17732247; CODEN: JDDSA Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Hybrid Gold Open Access Format The file format, physical medium, or dimensions of the resource online