Development and characterization of Fe2O3 nanoparticles coated with chitosan and folic acid for biomedical applications
- Title
- Development and characterization of Fe2O3 nanoparticles coated with chitosan and folic acid for biomedical applications
- Creator
- Kushwaha, Ravi Kant; Shah, Uzma Noor; Sandhwar, Vishal; Pandey, Sakshi; Thangavelu, Indumathi; AlGhamdi, AbdulAziz A.; Tadepalli, Srinivas
- Description
- Polymeric inorganic nanoparticles have emerged as promising nanomedicines due to their unique properties, offering enhanced antibacterial and anticancer effects. Thus, the study focus on the synthesis of Fe2O3 and Fe2O3 coated with chitosan and folic acid nanoparticles (Fe2O3-CS-FA NPs) mediated by Tagetes erecta (T. erecta) extract and assess their biological effects. The synthesized NPs are analysed by various characterisation techniques. FTIR spectroscopy of Fe2O3 and Fe2O3 -CS-FA NPs revealed characteristic peaks corresponding to Fe2O3, chitosan, and folic acid molecules. The XRD pattern confirmed the successful synthesis of Fe2O3 NPs and Fe2O3 -CS-FA NPs, indicating a rhombohedral structure. FESEM demonstrated spherical structures for both Fe2O3 and Fe2O3 -CS-FA NPs. Antimicrobial activity was assessed against various pathogens using the disk diffusion method, showing that Fe2O3-CS-FA NPs demonstrated superior antibacterial activity compared to Fe2O3 NPs. In terms of antioxidant activity, Fe2O3 -CS-FA NPs showed the highest scavenging activity against DPPH, outperforming Fe2O3 NPs. The anticancer activity of both Fe2O3 NPs and Fe2O3 -CS-FA NPs was tested against the HCT-116 human colon cancer cell line, where Fe2O3 -CS-FA NPs demonstrated greater anticancer activity with an IC50 value of 10.2 ?g/mL compared to Fe2O3 at 13.8 ?g/mL. Based on the findings of this research, there is a strong indication that Fe2O3 -CS-FA NPs hold significant potential as a nanomaterial well-suited for advanced biomedical applications in the industry. 2025 Indian Chemical Society
- Source
- Journal of the Indian Chemical Society;Volume;102;Issue;9;Article No.;101909;
- Date
- 01-01-2025
- Publisher
- Elsevier B.V.
- Subject
- Antibacterial activity; Anticancer activity; DPPH; Fe2O3 -CS-FA NPs; Marigold flowers
- Coverage
- Kushwaha R.K., Maharishi School of Pharmaceutical Sciences, Maharishi University of Information Technology, Uttar Pradesh, Lucknow, India; Shah U.N., Department of Genetics, School of Sciences, JAIN (Deemed-to-be University), Karnataka, India; Sandhwar V., Department of Chemical Engineering, PIT, Parul University, Gujarat, Vadodara, India; Pandey S., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, 140417, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; AlGhamdi A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
- Rights
- Restricted Access; Hardcopy may be available in the library
- Relation
- ISSN: 194522; CODEN: JICSA
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
Kushwaha, Ravi Kant; Shah, Uzma Noor; Sandhwar, Vishal; Pandey, Sakshi; Thangavelu, Indumathi; AlGhamdi, AbdulAziz A.; Tadepalli, Srinivas, “Development and characterization of Fe2O3 nanoparticles coated with chitosan and folic acid for biomedical applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22356.