Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Kharsodiya, Kiran; Das, Kaushik Pratim; Dhingra, Harish Kumar Title A name given to the resource Predictive value of IL-6, IL-1?, TNF-?, and vaginal pH in diagnosing vaginal microbial infections: A host-inflammatory axis perspective Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Journal of Microbiological Methods;Volume;237;Issue;;Article No.;107212; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.mimet.2025.107212" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.mimet.2025.107212</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105012545069?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105012545069?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Kharsodiya K., Department of Biosciences, School of Liberal Arts and Science, Mody University of Science and Technology, Rajasthan, Lakshmangarh, 332311, India; Das K.P., Department of Computer Science, School of Science, Christ University, Karnataka, Bengaluru, 560029, India; Dhingra H.K., Department of Biosciences, School of Liberal Arts and Science, Mody University of Science and Technology, Rajasthan, Lakshmangarh, 332311, India Description An account of the resource Microbial-associated vaginal infections are common among women of reproductive age and are linked to alterations in the local immune environment. Inflammatory biomarkers such as IL-6, IL-?, and TNF-?, along with vaginal pH have emerged as potential indicators of microbial dysbiosis. This study aimed to statistically evaluate the ability of these specific inflammatory cytokines and vaginal pH to identify infection status. Cytokine concentrations and vaginal pH were measured in clinically characterized samples. The group differences were analyzed using Mann-Whitney U tests and Cliff's Delta for effect size. ROC-AUC analysis was also performed to assess the discriminative power, and correlation heatmaps explored marker synergy. The infected individuals showed increased levels of all cytokines (p &lt; 0.001), with large effect size (? &gt; 0.9 for IL-6, IL-1?, TNF-?). Vaginal pH also differed significantly (? = 0.60). In addition, the combination of IL-6 and vaginal pH achieved excellent discriminative performance (AUC = 0.98). These findings suggest that IL-6, IL-1?, and TNF-?, when combined with vaginal pH, can function as reliable non-invasive biomarkers for the early detection and improved diagnostic triaging of vaginal microbial infections. 2024 Subject The topic of the resource Bacterial vaginosis; Inflammatory biomarkers; Vaginal microbial infections Publisher An entity responsible for making the resource available Elsevier B.V. Relation A related resource ISSN: 1677012; CODEN: JMIMD Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online