Glucose-Urea-Choline chloride: a versatile catalyst and solvent for the Kabachnik-Fields reaction
Kabachnik-fields reaction is a multi-component organic reaction that gives ?-aminophosphonates as products. The reaction between a carbonyl group, an amine, and amino phosphonates is noteworthy due to their antibacterial, antifungal, anti-HIV, anti-cancer, and analgesic characteristics. Low melting mixtures are also good alternatives for toxic catalysts and organic solvents. The use of organic solvent can be reduced in the Kabachnik-fields reaction by using low melting mixtures as a reaction media and catalyst. This method is cost-effective and safe. A practical synthesis of different derivatives of dialkylphosphonates was conducted. The solvent/catalyst is also easily recyclable. 2025 Elsevier B.V.
Anupama, B.; Alex, Andria Anna; Thomas, Jisha Mary; Cherian, Anila Rose; Theresa, Letcy V.
Journal of Molecular Liquids;Volume;434;Issue;;Article No.;128079;
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https://doi.org/10.1016/j.molliq.2025.128079 https://www.scopus.com/pages/publications/105009864235?origin=resultslist
Anupama B., Department of Chemistry, Christ University, Karnataka, Bengaluru, 560029, India; Alex A.A., Department of Chemistry, Christ University, Karnataka, Bengaluru, 560029, India; Thomas J.M., Department of Chemistry, Christ University, Karnataka, Bengaluru, 560029, India; Cherian A.R., Department of Chemistry, Christ University, Karnataka, Bengaluru, 560029, India; Theresa L.V., Department of Chemistry, Christ University, Karnataka, Bengaluru, 560029, India