Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Thangavelu, Indumathi; Tadepalli, Srinivas; Kasibatla, Murthy S. Title A name given to the resource Green synthesis of biocompatible L-Histidine-Modified NiFe2O4 Nanoparticles: A multifaceted approach toward cancer and bacterial therapy Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Journal of Molecular Structure;Volume;1352;Issue;;Article No.;144396; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.molstruc.2025.144396" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.molstruc.2025.144396</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105019076957?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105019076957?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Kasibatla M.S., Department of Chemistry, Applied Science Cluster, University of Petroleum and Energy Studies, Uttarakhand, Dehradun, 248007, India Description An account of the resource Cancer and infections caused by microbes remain serious global health threats, with multidrug resistance and toxicity associated with treatment constraining the efficacy of traditional therapies. In the present research, biocompatible L-histidine-functionalized nickel ferrite nanoparticles (NiFe2O4-LH) were green synthesized using of Clitoria ternatea flower extract and systematically evaluated for their therapeutic effects. Characterization established their spinel cubic structure, reduced crystallite size (14.4 nm), and enhanced stability when compared to bare NiFe2O4 (21.6 nm). UVvisible spectra revealed a blue shift with expanded band gap from 3.16 eV (NiFe2O4) to 3.92 eV (NiFe2O4-LH). The PL spectra revealed that the NiFe2O4-LH exhibited green emission at 516, 526 nm suggesting increased oxygen vacancies facilitating ROS production. The NiFe2O4-LH NPs demonstrated excellent antibacterial activity when compared to pure NiFe2O4. SEM analysis confirmed extensive bacterial membrane breakdown when exposed to NiFe2O4-LH. Cytotoxicity to MDA-MB-231 breast cancer cells showed a significant dose-dependent response with an IC50 of 12.41 ?g/mL. Biocompatibility assessments with zebrafish embryos supported negligible development toxicity, wherein NiFe?O?-LH-treated groups preserved normal morphology until 72 hpf compared to the bare NiFe2O4. 2025 Elsevier B.V. Subject The topic of the resource Antibacterial activity; Anticancer activity; Biocompatibility; L-histidine functionalization; MDA-MB-231; NiFe₂O₄; Zebrafish embryo Publisher An entity responsible for making the resource available Elsevier B.V. Relation A related resource ISSN: 222860; CODEN: JMOSB Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online