Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Bhunya, Debasis; Datta, Riya; Maity, Swapan; Maity, Tithi; Samanta, Bidhan Chandra Title A name given to the resource Anticancer potential of Ru(II) Schiff base complexes derived from picolinaldehyde and pyrazolyl amines: structural characterization and selective cytotoxicity toward SiHa cells Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Journal of Molecular Structure;Volume;1356;Issue;;Article No.;145138; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.molstruc.2025.145138" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.molstruc.2025.145138</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105026123617?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105026123617?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Bhunya D., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Datta R., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Maity S., School of Materials Science and Technology, Indian Institute of Technology (IIT), BHU, Varanasi, India; Maity T., Department of Chemistry, Prabhat Kumar College, Contai, West Bengal, Purba Medinipur, India; Samanta B.C., Department of Chemistry, Mugberia Gangadhar Mahavidyalaya, Bhupatinagar, West Bengal, Purba Medinipur, India Description An account of the resource Herein, we report the synthesis, complete structural characterization including spectroscopic and computational analyses, and in vitro anticancer efficacy assessment of three Ru(II) complexes against cervical carcinoma (SiHa) cell lines. Various spectroscopic techniques such as FTIR, 1H NMR, 13C NMR, 19F NMR and ESI-LCMS mass spectrometry were used to thoroughly characterize the synthesized ligands and the complexes. Density Functional Theory (DFT) calculations provided insights into their optimized geometry and electronic parameters, which were consistent with experimental observations. The cytotoxicity of three Ru(II) complexes was evaluated against SiHa and normal fibroblast (3T3-L1) cells using MTT assays at concentrations of 10100 g/mL for 2472 h, with 20 g/mL used for detailed temporal evaluation. All complexes showed strong, dose and time dependent cytotoxicity, reducing SiHa cell viability to 24 4%, 23 6%, and 33 5% respectively for complex 1, 2 and 3 after 72 h, while maintaining &gt;90% viability in fibroblasts. The IC?? values for complex 1, 2 and 3 (8.7 2.5, 8.4 2.3, and 7.8 1.5 g/mL) confirmed high potency and selectivity. Acridine orange and ethidium bromide (AO/EB) staining indicated apoptosis as the main cell death pathway, supported by morphological changes such as membrane blebbing and rounding. The DNA binding studies reveal that all the complexes have strong affinity toward DNA and interacted through intercalation mode. These findings highlight the complexes as selective and promising anticancer agents. 2025 Elsevier B.V. Subject The topic of the resource anticancer activity; Ru(II) complexes; Schiff base; SiHa, 3T3-L1 cell lines Publisher An entity responsible for making the resource available Elsevier B.V. Relation A related resource ISSN: 222860; CODEN: JMOSB Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online