Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Bhran, Ahmed A.; Ben Hamida, Mohamed Bechir; Thangavelu, Indumathi; Tadepalli, Srinivas Title A name given to the resource Development of biocompatible NiTi@?-TCP nanocomposite with improved antibacterial and anticancer activities for bone-related biomedical applications Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Journal of Molecular Structure;Volume;1368;Issue;;Article No.;146297; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.molstruc.2026.146297" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.molstruc.2026.146297</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105036165288?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105036165288?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Ben Hamida M.B., Deanship of Scientific Research, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia Description An account of the resource In the present study, ?-TCP and NiTi@?-TCP nanocomposite were synthesized using a modified solgel method. DLS analysis revealed hydrodynamic particle sizes of ?290 nm for ?-TCP and ?231 nm for NiTi@?-TCP, suggesting improved dispersion after NiTi modification. Optical studies showed a red shift in UVVis absorption from 321 nm (?-TCP) to 396 nm (NiTi@?-TCP) with a reduced band gap from 3.8 eV to 3.1 eV, indicating enhanced electronic interactions. Morphological analysis using SEM and HRTEM revealed nanoscale particles (?1530 nm) with clear lattice fringes and polycrystalline diffraction patterns. The NiTi@?-TCP nanocomposite exhibited enhanced antibacterial activity against S. aureus, S. pneumoniae, K. pneumoniae, and Escherichia coli, producing inhibition zones of 17, 13, 14, and 12 mm, respectively, compared with approximately 10 mm for pure ?-TCP. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values for S. aureus were 0.3 mg mL? and 0.5 mg mL? for NiTi@?-TCP, respectively, which were lower than those of ?-TCP (MIC 0.5 mg mL?; MBC 0.7 mg mL?). Histidine scavenger experiments demonstrated that reactive oxygen species (ROS) play a dominant role in bacterial inhibition. Biocompatibility studies using L929 fibroblast cells showed high cell viability (&gt;87% at 150 ?g mL?), confirming good cytocompatibility. In contrast, the nanocomposite exhibited enhanced anticancer activity against MG-63 osteosarcoma cells, with an IC?? value of 115 ?g mL?, compared with 138 ?g mL? for ?-TCP. These results demonstrate that NiTi@?-TCP nanocomposite possesses improved antibacterial and anticancer properties while maintaining good biocompatibility, making it a promising multifunctional biomaterial for biomedical and bone-related therapeutic applications. 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies. Subject The topic of the resource Antibacterial activity; Bone cancer therapy; Cytocompatibility; MG-63 osteosarcoma cells; NiTi coated ?-TCP nanocomposite; Reactive oxygen species; ?-Tricalcium phosphate Publisher An entity responsible for making the resource available Elsevier B.V. Relation A related resource ISSN: 222860; CODEN: JMOSB Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online