ItemArticle

Smartphone-integrated quantitative determination of bilirubin using luminescent carbon nanoparticles

Title
Smartphone-integrated quantitative determination of bilirubin using luminescent carbon nanoparticles
Creator
Jibin, P.O.; Anila, E.I.; Anoop, K.K.; Ann Mary, K.A.
Description
Herein, using a green, cost-effective, and sustainable biomass precursor, luminescent carbon nanoparticles (CNP) are synthesized for selective bilirubin quantification. From high-resolution transmission electron microscopy (HRTEM) image, the prepared CNP exhibited spherical morphology and the crystallite size ranges from 8 to 16 nm. X-ray photoelectron spectroscopy (XPS) analysis confirmed the presence of both sp2 and sp3 hybridized carbon bonds within the carbon nanoparticles (CNP). Furthermore, Dynamic Light Scattering (DLS) analysis was performed to determine the hydrodynamic diameter of the CNP and the average particle size was found to be approximately 12.94 0.19 nm. Under ultraviolet (UV) radiation of 350 nm wavelength, the CNP displayed excitation dependent emission characteristics, having an average lifetime of 4.4 ns. The fluorescence intensity of carbon nanoparticles reduced considerably in the presence of Fe3+ ions and fluorescence turn ON was achieved upon the addition of different concentrations of bilirubin. The probe displayed remarkable selectivity towards bilirubin over other potential interferences. Using a sensing platform based on a mobile phone application, the fluorescent probe exhibited a limit of detection (LOD) of 32 nM. Moreover, the fluorescent probe was efficiently employed for the detection of bilirubin in human serum and urine specimens. This cost-effective carbon-based turn-off-on fluorescent sensor makes it easy to detect bilirubin, through visual inspection under ultraviolet light, thereby enabling prompt diagnosis. 2025 Elsevier B.V.
Source
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy;Volume;344;Issue;;Article No.;126738;
Date
01-01-2026
Publisher
Elsevier B.V.
Subject
Bilirubin sensing; Carbon nanoparticles; Fluorescence quenching; Mobile platform sensing
Coverage
Jibin P.O., Advanced Nanomaterials Research Division, Department of Physics, Research Center - University of Calicut, St. Thomas College (Autonomous), Thrissur, 680 001, India; Anila E.I., Optoelectronics and Nanomaterials Research Laboratory, Department of Physics, Union Christian College, Aluva, Kerala, 683102, India, Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, 560029, India; Anoop K.K., Department of Physics, Cochin University of Science & Technology, Kerala, Cochin, 22, India; Ann Mary K.A., Advanced Nanomaterials Research Division, Department of Physics, Research Center - University of Calicut, St. Thomas College (Autonomous), Thrissur, 680 001, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 13861425; CODEN: SAMCA
Format
online
Language
English
Type
Article

Citation

Jibin, P.O.; Anila, E.I.; Anoop, K.K.; Ann Mary, K.A., “Smartphone-integrated quantitative determination of bilirubin using luminescent carbon nanoparticles,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22450.

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