Advancing precision medicine: Uncovering biomarkers and strategies to mitigate immune-related adverse events in immune checkpoint inhibitors therapy
subject: Biomarkers; Immuno-related adverse events; Immunosuppressants; Immunotherapy; Immunotoxicity; Precision medicine
description: Immune-related adverse events (irAEs) can have a major influence on patient outcomes, but their usage is frequently confounded by immune checkpoint inhibitors (ICIs), which have revolutionized cancer treatment by increasing anti-tumor immunity. With a focus on immunological dysregulation and the resulting tissue-specific toxicities, this review clarifies the fundamental processes of irAEs. We look at contemporary clinical treatment techniques to lessen the impact of these adverse events, such as the application of immunosuppressants and patient monitoring procedures. Additionally, it is emphasized how future research is necessary to find predictive biomarkers that can forecast the development of irAEs, allowing for early intervention and individualized therapy methods. In order to improve the therapeutic index of ICIs, we also examine the crucial balance between optimizing anti-tumor activity and reducing immunotoxicity. This study aims to further the existing discussion on enhancing the safety and effectiveness of ICI medicines, which will eventually improve cancer patient care, by pointing out possible research avenues. 2025 The Authors
creator: Nityashree, K.L.; Rachitha, P.; Hanchinmane, Shilpa; Raghavendra, Vinay B.
source: Toxicology Reports;Volume;14;Issue;;Article No.;102035;
publisher: Elsevier Inc.
date: 01-01-2025
rights: All Open Access; Gold Open Access; Green Open Access
relation: ISSN: 22147500;
format: online
language: English
type: Article
coverage: Nityashree K.L., Christ University, Department of Psychology, Bangalore, India; Rachitha P., PG Department of Biotechnology, Teresian College, Siddarthanagar, Mysuru, 570011, India; Hanchinmane S., PG Department of Biotechnology, Teresian College, Siddarthanagar, Mysuru, 570011, India; Raghavendra V.B., PG Department of Biological Sciences, Jyoti Nivas College, Autonomous Koramangala, Bengaluru, 560095, India