Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Nityashree, K.L.; Rachitha, P.; Hanchinmane, Shilpa; Raghavendra, Vinay B. Title A name given to the resource Advancing precision medicine: Uncovering biomarkers and strategies to mitigate immune-related adverse events in immune checkpoint inhibitors therapy Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Toxicology Reports;Volume;14;Issue;;Article No.;102035; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.toxrep.2025.102035" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.toxrep.2025.102035</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105004269359?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105004269359?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nityashree K.L., Christ University, Department of Psychology, Bangalore, India; Rachitha P., PG Department of Biotechnology, Teresian College, Siddarthanagar, Mysuru, 570011, India; Hanchinmane S., PG Department of Biotechnology, Teresian College, Siddarthanagar, Mysuru, 570011, India; Raghavendra V.B., PG Department of Biological Sciences, Jyoti Nivas College, Autonomous Koramangala, Bengaluru, 560095, India Description An account of the resource Immune-related adverse events (irAEs) can have a major influence on patient outcomes, but their usage is frequently confounded by immune checkpoint inhibitors (ICIs), which have revolutionized cancer treatment by increasing anti-tumor immunity. With a focus on immunological dysregulation and the resulting tissue-specific toxicities, this review clarifies the fundamental processes of irAEs. We look at contemporary clinical treatment techniques to lessen the impact of these adverse events, such as the application of immunosuppressants and patient monitoring procedures. Additionally, it is emphasized how future research is necessary to find predictive biomarkers that can forecast the development of irAEs, allowing for early intervention and individualized therapy methods. In order to improve the therapeutic index of ICIs, we also examine the crucial balance between optimizing anti-tumor activity and reducing immunotoxicity. This study aims to further the existing discussion on enhancing the safety and effectiveness of ICI medicines, which will eventually improve cancer patient care, by pointing out possible research avenues. 2025 The Authors Subject The topic of the resource Biomarkers; Immuno-related adverse events; Immunosuppressants; Immunotherapy; Immunotoxicity; Precision medicine Publisher An entity responsible for making the resource available Elsevier Inc. Relation A related resource ISSN: 22147500; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Format The file format, physical medium, or dimensions of the resource online