Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Singha, Souvik; Chellathurai, Melbha Starlin; Mahmood, Syed; Romero, Eder Lilia; Randhawa, Jaspreet Kaur; Kumar, Mohit; Thomas, Sabu; Chen, Wen-Cheng; Ghosal, Kajal Title A name given to the resource Thermosensitive In-situ gel based on halloysite nanotube/chitosan for site-specific delivery of aceclofenac Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Journal of Pharmaceutical Sciences;Volume;115;Issue;5;Article No.;104228; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.xphs.2026.104228" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.xphs.2026.104228</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105032810192?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105032810192?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Singha S., Department of Pharmaceutical Technology, Jadavpur University, India; Chellathurai M.S., Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, 50603, Malaysia, Department of Pharmaceutics, School of Pharmacy, Joy University, Raja Nagar, Vaddakkankulam, Tamil Nadu, Tirunelveli, 627116, India; Mahmood S., Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, 50603, Malaysia, Universiti Malaya Research Centre for Biopharmaceuticals and Advanced Therapeutics (UBAT), Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Pathum Wan, 10330, Thailand; Romero E.L., Nanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Pe 352, Bernal, 1876, Argentina; Randhawa J.K., School of Mechanical &amp; Materials Engineering, Indian Institute of Technology Mandi, India; Kumar M., Chitkara College of Pharmacy, Chitkara University, Punjab, Rajpura, 140401, India; Thomas S., IIUCNN, Mahatma Gandhi University, Kerala, Kottayam, 686 560, India, Department of Physics and Electronics, CHRIST (Deemed to Be University), Karnataka, Bengaluru, 560029, India, Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Johannesburg, Doornfontein, 2028, South Africa; Chen W.-C., Department of Fiber and Composite Materials, Feng Chia University, Taichung, 407, Taiwan, Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 807, Taiwan, School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan; Ghosal K., Department of Pharmaceutical Technology, Jadavpur University, India Description An account of the resource Periodontitis, a severe and chronic inflammatory gum disease, necessitates the development of advanced drug delivery strategies due to the limitations of conventional therapies, such as rapid drug clearance and inadequate site-specific retention. This study addresses these challenges by formulating and evaluating a novel aceclofenac-loaded halloysite nanotube (HNT) In-situ gel designed for effective local treatment of periodontitis. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) known for its potent anti-inflammatory action and reduced gastrointestinal side effects, was encapsulated within HNTs to achieve sustained drug release and enhanced therapeutic efficacy. These drug-loaded HNTs were subsequently incorporated into a thermosensitive In-situ gelling system composed of medium molecular weight chitosan, sodium bicarbonate, and sodium ?-glycerophosphate. This gel formulation demonstrated favourable properties, including syringeability, swelling capacity, and temperature-responsive gelation at physiological conditions. The comprehensive characterization techniques such as FTIR, SEM, TEM, PXRD, DSC/TGA, confirmed successful drug encapsulation, structural stability, and uniform distribution within the gel matrix. The in vitro release studies revealed a sustained drug release profile, following zero-order and KorsmeyerPeppas kinetics, indicative of a Super Case-II transport mechanism. This novel, thermoresponsive local drug delivery system shows strong potential to improve the clinical management of periodontitis by providing prolonged therapeutic action, targeted delivery, and improved patient compliance. 2026 American Pharmacists Association. Subject The topic of the resource Aceclofenac; Chitosan; Halloysite nanotube; In-situ gel; Periodontitis Publisher An entity responsible for making the resource available Elsevier B.V. Relation A related resource ISSN: 223549; CODEN: JPMSA Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online