Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Pakrashy, Sourav; Das, Manik; Manna, Sounik; Choudhury, Sujata Maiti; Shinziya, Hazeena; Das, Bhriguram; Dolai, Malay; Das, Avijit Kumar Title A name given to the resource Development of a natural product-based selective fluorescent sensor for Cu2+ and DNA/protein: insights from docking, DFT, cellular imaging and anticancer activity Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Analytical Methods;Volume;17;Issue;30;pp.6160-6169 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1039/d5ay00778j" target="_blank" rel="noreferrer noopener">https://doi.org/10.1039/d5ay00778j</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105012153780?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105012153780?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pakrashy S., Department of Chemistry, Prabhat Kumar College, WB, Purba Medinipur, 721404, India; Das M., Department of Chemistry, Prabhat Kumar College, WB, Purba Medinipur, 721404, India; Manna S., Biochemistry, Molecular Endocrinology and Reproductive Physiology Laboratory, Department of Human Physiology, Vidyasagar University, WB, Midnapore, 721102, India; Choudhury S.M., Biochemistry, Molecular Endocrinology and Reproductive Physiology Laboratory, Department of Human Physiology, Vidyasagar University, WB, Midnapore, 721102, India; Shinziya H., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India; Das B., Department of Chemistry, Vidyasagar University, WB, Paschim Medinipur, 721102, India; Dolai M., Department of Chemistry, Prabhat Kumar College, WB, Purba Medinipur, 721404, India; Das A.K., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India Description An account of the resource The natural product seselin (SS), was synthesized and characterized spectroscopically for the selective detection of Cu2+ and biomolecules such as ct-DNA and BSA. The probe exhibits strong bluish emission in a MeOH-H2O (7 : 3, v/v) HEPES buffer solution (pH 7.4) at 453 nm. Upon exposure to Cu2+, the SS solution shows a selective fluorescence turn-off with a binding constant of 2.13 105 M?1 and a detection limit of 3.48 10?8 M. The HOMO-LUMO energy gap of the probe SS decreases from ?E = 7.97 eV to ?E = 7.77 eV upon binding with Cu2+, indicating enhanced stability due to ligand-metal complex formation. Significantly, the ligand SS exhibits fluorescence enhancement in the presence of ct-DNA and BSA, resulting in a visible fluorescence change from colorless to blue, with binding constants of 4.8 104 M?1 and 4.7 104 M?1, respectively. The binding interactions of SS with biomacromolecules have been explored through molecular docking studies, revealing that the probe can serve as a promising anti-cancer and anti-viral agent. Furthermore, the probe SS demonstrates potent anticancer activity in treatments involving MCF-7 and HLC cells. Additionally, the probe SS is capable of detecting intracellular Cu2+ in live MCF-7 cell lines. 2025 The Royal Society of Chemistry. Publisher An entity responsible for making the resource available Royal Society of Chemistry Relation A related resource ISSN: 17599660; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Hybrid Gold Open Access Format The file format, physical medium, or dimensions of the resource online