Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Vishnu, S.; Das, Avijit Kumar; Karan, Gouri; Choudhury, Sujata Maiti Title A name given to the resource Fluorescence switching via competitive ESIPT and spirolactam ring opening in a multifunctional rhodamine B probe for selective detection of Cu2+ and OCl?: theoretical insights with anticancer and biosensor activity Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Materials Advances;Volume;6;Issue;13;pp.4499-4512 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1039/d5ma00517e" target="_blank" rel="noreferrer noopener">https://doi.org/10.1039/d5ma00517e</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105007940210?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105007940210?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Vishnu S., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India; Das A.K., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India; Karan G., Cancer Nanotherapeutics Laboratory, Biochemistry, Molecular Endocrinology and Reproductive Physiology Division, Department of Human Physiology, Vidyasagar University, West Bengal, Midnapore, 721102, India; Choudhury S.M., Cancer Nanotherapeutics Laboratory, Biochemistry, Molecular Endocrinology and Reproductive Physiology Division, Department of Human Physiology, Vidyasagar University, West Bengal, Midnapore, 721102, India Description An account of the resource A multifunctional ESIPT-based rhodamine-derived probe (BHS) was synthesized and developed as a colorimetric and fluorometric sensor for the selective detection of copper (Cu2+) and hypochlorite (OCl?) in aqueous solutions. Initially, BHS exhibits intense whitish blue fluorescence due to the active excited-state intramolecular proton transfer (ESIPT) mechanism within the molecule. However, upon interaction with Cu2+ and OCl?, noticeable changes in absorption and fluorescence occur, attributed to the inhibition of ESIPT resulting from analyte binding with BHS, leading to spirolactam ring opening. Furthermore, significant Stokes shifts in absorption (?? = 34 nm and 170 nm for Cu2+, and 163 nm for OCl?) and emission (?? = 67 nm for both Cu2+ and OCl?) further confirm this transformation. The spirolactam ring opening is induced by Cu2+ coordination, whereas for OCl?, it is triggered by oxidative cleavage. To explore potential biological applications, fluorescence titration experiments were conducted to study the interactions of the BHS-Cu2+ complex with ct-DNA and the transport protein bovine serum albumin (BSA). Additionally, molecular docking studies were performed to assess these interactions, while DFT calculations were employed to optimize the structures of BHS and its Cu2+ complex. The fluorescence changes of BHS in the presence of Cu2+ and OCl? in biological samples have been examined by the anticancer and biosensor activity of BHS in HCT-116 colorectal cancer cells. 2025 RSC. Publisher An entity responsible for making the resource available Royal Society of Chemistry Relation A related resource ISSN: 26335409; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access Format The file format, physical medium, or dimensions of the resource online