Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Manuel, Manju; Kanchi, Suvardhan; Losetty, Venkatramana Title A name given to the resource Exploring a GE/Nafion/Co-MOF nanosheets/CuO NPs/GOx powered electrochemical biosensor for ultrasensitive detection of rebaudioside A Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Nanoscale Advances;Volume;8;Issue;1;pp.167-180 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1039/d5na00591d" target="_blank" rel="noreferrer noopener">https://doi.org/10.1039/d5na00591d</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105022739012?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105022739012?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Manuel M., Department of Chemistry, CHRIST University, Bengaluru, 560 029, India, Centre for Renewable Energy and Environmental Sustainability, CHRIST University, Bengaluru, 560 029, India; Kanchi S., Department of Chemistry, CHRIST University, Bengaluru, 560 029, India, Centre for Renewable Energy and Environmental Sustainability, CHRIST University, Bengaluru, 560 029, India; Losetty V., Department of Chemistry, Vel Tech Rangarajan Dr Sagunthala R&amp;D Institute of Science and Technology, Avadi, Chennai, 600 062, India Description An account of the resource Rebaudioside A (Reb A) is a natural, non-nutritive sweetener highly prevalent in the global sweetener market and widely preferred by consumers. In this study, an advanced electrochemical biosensor was developed for sensing Reb A, using a modified graphite rod electrode extracted from discharged ZnC batteries. The electrode was fabricated using a layer-by-layer strategy with Nafion, Co-MOF nanosheets, CuO NPs, and glucose oxidase (GOx) enzyme. The nanomaterials were characterized by UV-vis, FTIR, DLS, zeta potential measurements, XRD, Raman, SEM, TEM, EDS, and XPS techniques. Electrochemical characterization via Cyclic Voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS) revealed a significant enhancement in electrical conductivity and increased electroactive surface area. The designed biosensor exhibited a sharp oxidation peak at 0.16 V due to ester bond cleavage in Reb A, which was further amplified in the presence of GOx, resulting from hydroxyl oxidation and hydrogen peroxide generation. Differential pulse voltammetry (DPV) demonstrated a linear response over a concentration range of 2.014 M (R2 = 0.993) with a limit of detection (LOD) of 0.23 M. The sensor displayed excellent analytical performance, with repeatability, reproducibility (RSD = 3.9%), and stability. Additionally, recovery studies confirmed its accuracy, ranging from 97% to 98.17%. Further, the molecular docking studies confirmed strong Reb AGOx interactions (?7.26 kcal mol?1), supporting the biosensor's specificity. The developed biosensor demonstrates excellent analytical performance, making it highly suitable for routine laboratory analysis of sweeteners in complex food matrices. This journal is The Royal Society of Chemistry, 2026 Publisher An entity responsible for making the resource available Royal Society of Chemistry Relation A related resource ISSN: 25160230; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Format The file format, physical medium, or dimensions of the resource online