ItemArticle

Mechanistic elucidation of irreversible chemodosimetric sensing of hydrazine through structural, computational, and bioimaging analyses

Title
Mechanistic elucidation of irreversible chemodosimetric sensing of hydrazine through structural, computational, and bioimaging analyses
Creator
Avala, Priyanka; Kumar, Malavika S; Das, Avijit Kumar; Sardar, Ankan; Maity, Tilak Raj; Samanta, Aveek; Dolai, Malay
Description
A fluorescent chemodosimeter, DBA, has been developed for the selective detection of hydrazine via an irreversible reaction pathway that leads to fluorescence enhancement. The crystal structure of the ligand has been successfully determined. The sensing mechanism involves the conversion of a hydrazide derivative into a hydrazone derivative, as confirmed by both 1H NMR and mass spectrometry. Upon interaction of DBA with hydrazine, the probe exhibits a significant decrease in absorbance at 366 nm and 279 nm, along with a three fold enhancement in fluorescence intensity at 423 nm, achieving a detection limit of 0.37 M. The detection mechanism has also been supported by theoretical analysis using density functional theory (DFT) calculations. For practical applications, DBA has been employed in plant-based cell imaging to monitor hydrazine accumulation in Lathyrus sativus L. (grass pea). Overall, DBA is a simple, effective, and promising fluorescent probe for hydrazine detection in diverse fields such as environmental monitoring, food safety, and biological risk assessment. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique, 2026
Source
New Journal of Chemistry;Volume;50;Issue;1;pp.433-440
Date
01-01-2026
Publisher
Royal Society of Chemistry
Coverage
Avala P., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India, Centre for Renewable Energy and Environmental Sustainability, Christ University Karnataka, 560029, India; Kumar M.S., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India, Centre for Renewable Energy and Environmental Sustainability, Christ University Karnataka, 560029, India; Das A.K., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India, Centre for Renewable Energy and Environmental Sustainability, Christ University Karnataka, 560029, India; Sardar A., Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Mohanpur, Kolkata, 741246, India; Maity T.R., Department of Biotechnology, Haldia Institute of Technology, Haldia Purba, West Bengal, Medinipur, 721657, India; Samanta A., Department of Botany, Prabhat Kumar College, Contai Purba Medinipur, W.B, Medinipur, 721404, India; Dolai M., Department of Chemistry, Prabhat Kumar College Purba, West Bengal, Medinipur, 721404, India
Rights
All Open Access; Hybrid Gold Open Access
Relation
ISSN: 11440546; CODEN: NJCHE
Format
online
Language
English
Type
Article

Citation

Avala, Priyanka; Kumar, Malavika S; Das, Avijit Kumar; Sardar, Ankan; Maity, Tilak Raj; Samanta, Aveek; Dolai, Malay, “Mechanistic elucidation of irreversible chemodosimetric sensing of hydrazine through structural, computational, and bioimaging analyses,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22570.

Output Formats