Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Bhunya, Debasis; Datta, Riya; Maity, Ribhu; Saha, Alipe; Sen, Sujata; Brandao, Paula; Pattanayak, Satyajit; Maity, Tithi; Sarkar, Keka; Samanta, Bidhan Chandra Title A name given to the resource Design and synthesis of bioactive Ru(II) complexes: antibacterial activity, biocompatibility and biomolecular binding Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived RSC Advances;Volume;15;Issue;50;pp.42573-42587 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1039/d5ra05336f" target="_blank" rel="noreferrer noopener">https://doi.org/10.1039/d5ra05336f</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105026054222?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105026054222?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Bhunya D., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Datta R., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Maity R., Department of Chemistry, Mugberia Gangadhar Mahavidyalaya, Bhupatinagar, Purba Medinipur, West Bengal, 721425, India; Saha A., Department of Microbiology, University of Kalyani, West Bengal, India; Sen S., Department of Microbiology, University of Kalyani, West Bengal, India; Brandao P., Departamento de Quica, CICECO, Universidade de Aveiro, Aveiro, 3810-193, Portugal; Pattanayak S., Department of Chemistry, Mugberia Gangadhar Mahavidyalaya, Bhupatinagar, Purba Medinipur, West Bengal, 721425, India; Maity T., Department of Chemistry, Prabhat Kumar College, Purba Medinipur, West Bengal, Contai, 721401, India; Sarkar K., Department of Microbiology, University of Kalyani, West Bengal, India; Samanta B.C., Department of Chemistry, Mugberia Gangadhar Mahavidyalaya, Bhupatinagar, Purba Medinipur, West Bengal, 721425, India Description An account of the resource Ruthenium(ii) complexes with N- and S-donor ligands have emerged as promising alternatives to conventional antibiotics due to their stability, biocompatibility, and ability to interact with biological macromolecules. In this work, a series of four Ru(ii)thiazolidine complexes, [Ru(ii)(L1L4)(p-cymene)Cl]PF6, were synthesized and structurally characterized using spectroscopic techniques and X-ray crystallography. Their interactions with DNA and proteins showed partial groove binding with calf thymus DNA and a static quenching mechanism with bovine serum albumin (BSA). Biological investigations revealed that two of the complexes exhibited strong antioxidant activity and significant antibacterial effects against methicillin-resistant Staphylococcus aureus (MRSA) and Klebsiella pneumonia (KP). Moreover, hemolysis assays confirmed their favourable biocompatibility. These results highlight Ru(ii)thiazolidine frameworks as promising candidates for antimicrobial drug development. This study not only underscores their therapeutic potential but also advances the role of ruthenium-based coordination chemistry in addressing the persistent challenge of antibiotic resistance. This journal is The Royal Society of Chemistry, 2025 Publisher An entity responsible for making the resource available Royal Society of Chemistry Relation A related resource ISSN: 20462069; CODEN: RSCAC Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Format The file format, physical medium, or dimensions of the resource online