Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Durgi, Nikita Kush; Pujar, Prasad Pralhad Title A name given to the resource Highly emissive dibenzofuranfluorophores with aggregation-induced emission for bioimaging in HeLa cell lines Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived RSC Advances;Volume;15;Issue;42;pp.35253-35264 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1039/d5ra05626h" target="_blank" rel="noreferrer noopener">https://doi.org/10.1039/d5ra05626h</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105017120139?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105017120139?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Durgi N.K., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India, Centre for Renewable Energy and Environmental Sustainability, Christ University Bangalore, 560029, India; Pujar P.P., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India, Centre for Renewable Energy and Environmental Sustainability, Christ University Bangalore, 560029, India Description An account of the resource Dibenzo[b,d]furans, structural analogs of furan, represent an emerging class of promising molecules whose solid-state emission properties remain largely unexplored. The aim of the present work is to design and synthesize new dibenzo[b,d]furan-based organic fluorophores for bioimaging applications. The synthesis involved a single-step Schiff base reaction of 4-(dibenzo[b,d]furan-4-yl)aniline with two different ortho-hydroxy aldehydes, furnishing DBF1 and DBF2 in high yields. Both fluorophores DBF1 and DBF2 exhibited high fluorescence in their solid and aggregated states. The photophysical properties in solution, solid, and aggregated states were investigated using absorbance and emission spectroscopy. The aggregation process was confirmed by the particle size analysis using dynamic light scattering (DLS). The cytotoxicity of the molecules was investigated against HeLa cell lines by the standard MTT assay. DBF1 and DBF2 demonstrated exceptional photoluminescence with quantum yields reaching up to 17.89% and 2.26% respectively, highlighting their potential as excellent materials for imaging applications. Both DBF1 and DBF2 exhibited significant toxicity towards HeLa cells with IC50 values of 42.08 ?g ml?1 and 39.74 ?g ml?1, respectively, showcasing notable anti-proliferative activity against HeLa cells. Both fluorophores exhibited excellent emission in HeLa cells with mean relative fluorescence intensities of 1.008 0.77 a.u. and 1.44 0.65 a.u. for DBF1 and DBF2, respectively. Thus, this work presents the lesser explored dibenzo[b,d]furan-based organic fluorophores for bioimaging applications with potential inhibitory activity against HeLa cells. 2025 The Royal Society of Chemistry. Publisher An entity responsible for making the resource available Royal Society of Chemistry Relation A related resource ISSN: 20462069; CODEN: RSCAC Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Format The file format, physical medium, or dimensions of the resource online