Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Manna, Sounik; Mondal, Suman; Chaudhuri, Angsuman Das; Karan, Gouri; Dey, Surya Kanta; Giri, Dibyendu; Dolai, Malay; Das, Avijit Kumar; Choudhury, Sujata Maiti Title A name given to the resource Rationally engineered PEGylatedl-citrulline functionalized baicalein encapsulated HSA nanopolymer guided by molecular docking for tumor microenvironment responsive and redox modulated colon cancer therapy Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived RSC Advances;Volume;16;Issue;1;pp.667-686 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1039/d5ra08629a" target="_blank" rel="noreferrer noopener">https://doi.org/10.1039/d5ra08629a</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105026343641?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105026343641?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Manna S., Cancer Nanotherapeutics and Toxicology Research Laboratory, Biochemistry, Molecular Endocrinology, and Reproductive Physiology Division, Department of Human Physiology, Vidyasagar University Midnapore, West Bengal, 721102, India; Mondal S., Cancer Nanotherapeutics and Toxicology Research Laboratory, Biochemistry, Molecular Endocrinology, and Reproductive Physiology Division, Department of Human Physiology, Vidyasagar University Midnapore, West Bengal, 721102, India; Chaudhuri A.D., Cancer Nanotherapeutics and Toxicology Research Laboratory, Biochemistry, Molecular Endocrinology, and Reproductive Physiology Division, Department of Human Physiology, Vidyasagar University Midnapore, West Bengal, 721102, India; Karan G., Cancer Nanotherapeutics and Toxicology Research Laboratory, Biochemistry, Molecular Endocrinology, and Reproductive Physiology Division, Department of Human Physiology, Vidyasagar University Midnapore, West Bengal, 721102, India; Dey S.K., Department of Allied Health Sciences, Brainware University Barasat, Kolkata West Bengal, 700125, India; Giri D., Cancer Nanotherapeutics and Toxicology Research Laboratory, Biochemistry, Molecular Endocrinology, and Reproductive Physiology Division, Department of Human Physiology, Vidyasagar University Midnapore, West Bengal, 721102, India; Dolai M., Department of Chemistry, Prabhat Kumar College Purba, Medinipur West Bengal, 721404, India; Das A.K., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India; Choudhury S.M., Cancer Nanotherapeutics and Toxicology Research Laboratory, Biochemistry, Molecular Endocrinology, and Reproductive Physiology Division, Department of Human Physiology, Vidyasagar University Midnapore, West Bengal, 721102, India Description An account of the resource Colon cancer remains a major global health burden characterized by uncontrolled proliferation, oxidative stress, and poor responsiveness to conventional therapies, underscoring the need for biocompatible and targeted nanotherapeutic interventions. In this study, a novel pH-responsive human serum albumin-based nanocarrier, HSA-BA@PEG-LC NPs, was designed for the efficient and selective delivery of baicalein (BA) to colon cancer cells. Molecular docking analysis demonstrated strong binding affinities of BA with Hsp90 inhibitors and with human serum albumin (HSA), as well as a notable interaction between l-citrulline (LC) and the cationic amino acid transporter 1 (CAT-1), highlighting their potential roles in anticancer modulation. The engineered nanoparticles exhibited a uniform spherical morphology (232 nm), low polydispersity index (PDI &lt; 0.3), and high colloidal stability (?27.21 mV). Spectroscopic analyses (FTIR and 1H NMR) confirmed successful encapsulation of BA and PEG-LC surface conjugation, with an encapsulation efficiency of 86.62% and pH-dependent sustained release favoring acidic tumor conditions. In HCT-116 cells, HSA-BA@PEG-LC NPs demonstrated enhanced internalization, strong cytoplasmic accumulation, and pronounced cytotoxicity (IC50 = 5.42 g mL?1), while maintaining safety toward normal lymphocytes. Mechanistically, treatment induced elevated ROS levels, GSH depletion, mitochondrial depolarization, nuclear condensation, cytoskeletal collapse, and G0/G1 cell-cycle arrest. Furthermore, the formulation displayed potent antioxidant activity across DPPH, NO, SOD, and lipid peroxidation assays, with IC50 values approaching ascorbic acid, validating synergistic PEG-LC functionalization and HSA-mediated stabilization as a promising redox-driven nanoplatform for targeted colon cancer therapy. This journal is The Royal Society of Chemistry, 2026 Publisher An entity responsible for making the resource available Royal Society of Chemistry Relation A related resource ISSN: 20462069; CODEN: RSCAC Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Format The file format, physical medium, or dimensions of the resource online