Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Shinziya, Hazeena; Das, Avijit Kumar; Kumar, Malavika S; Nag, Anish; Dolai, Malay Title A name given to the resource Bimodal sensor employing a novel approach for simultaneous selective detection of Ni2+ and biomolecules via turn-on fluorescence supported by DFT and molecular docking Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Sensors and Diagnostics;Volume;4;Issue;7;pp.622-630 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1039/d5sd00028a" target="_blank" rel="noreferrer noopener">https://doi.org/10.1039/d5sd00028a</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105006655977?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105006655977?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Shinziya H., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India; Das A.K., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India; Kumar M.S., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India; Nag A., Department of Life Science, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India; Dolai M., Department of Chemistry, Prabhat Kumar College, Purba Medinipur, West Bengal, Contai, 721404, India Description An account of the resource A bimodal sensor, (E)-2-(4-(diphenylamino)styryl)-1-methylquinolin-1-ium (DSM), was designed and synthesized for the simultaneous fluorescence turn-on detection of Ni2+ ion and biomolecules such as ct-DNA, BSA, and ovalbumin. Due to its distinct size and steric properties, DSM exhibits different binding modes when interacting with Ni2+ and DNA/proteins. The probe DSM possesses dual functionalities, allowing it to selectively detect Ni2+ at one binding site while interacting with ct-DNA, BSA, and ovalbumin at another. Thus, interactions of DSM with Ni2+ result in fluorescence enhancement at 377 nm and 400 nm, with a detection limit of 1.53 ?M and binding constant of 1.2 106 M?1. Moreover, the binding of DSM with Ni2+ has been demonstrated via UV-vis, mass spectra, Jobs plots and DFT analysis. Conversely, binding of DSM with ct-DNA, ovalbumin and BSA led to an increase in the fluorescence at 425 nm and 435 nm, respectively, with the detection limit at micromolar (ct-DNA) and nanomolar (BSA and ovalbumin) levels. These interactions have been validated through UV-vis spectroscopy, fluorescence studies, and molecular docking analysis. Thus, this study underscores the potential of DSM as a versatile tool for simultaneous detection of both metal ions and biomolecules with a unique bimodal approach. 2025 RSC. Publisher An entity responsible for making the resource available Royal Society of Chemistry Relation A related resource ISSN: 26350998; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access Format The file format, physical medium, or dimensions of the resource online