Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Bhunya, Debasis; Datta, Riya; Maity, Swapan; Sahoo, Subhasish; Samanta, Bidhan Chandra Title A name given to the resource Engineering Ru(ii) Schiff base complexes as biofunctional materials: cytotoxic and cell imaging perspectives Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived New Journal of Chemistry;Volume;50;Issue;12;pp.5266-5276 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1039/d6nj00553e" target="_blank" rel="noreferrer noopener">https://doi.org/10.1039/d6nj00553e</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105032238479?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105032238479?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Bhunya D., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Datta R., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Maity S., School of Materials Science and Technology, Indian Institute of Technology (IIT), BHU, Varanasi, India; Sahoo S., Department of Chemistry, National Institute of Technology, Rourkela, 769008, India; Samanta B.C., Department of Chemistry, Mugberia Gangadhar Mahavidyalaya, Bhupatinagar, Purba Medinipur, West Bengal, India Description An account of the resource Four bromine-substituted Ru(ii)-arene Schiff base complexes derived from bromo-picolinaldehyde and 3-(1H-pyrazol-1-yl)propan-1-amine were examined for their cytotoxic behaviour toward cervical cancer (SiHa) and normal fibroblast (3T3-L1) cells using MTT-based in vitro assays. The ligands and complexes were comprehensively characterized by FTIR; 1H, 13C, and 19F NMR; and ESI-LCMS analyses. Single-crystal X-ray diffraction (SCXRD) confirmed the molecular structure of complex 3, while PXRD validated the crystalline nature of complexes 2 and 4. Density functional theory (DFT) calculations further supported the experimental data by revealing optimized geometries and key electronic descriptors. All complexes exhibited time- and dose-dependent anticancer effects, with complexes 24 showing the greatest cytotoxicity toward the SiHa cells (viability at 72 h: 20% 3%, 31% 3%, and 29% 3%, respectively) while maintaining high viability in normal fibroblasts (&gt;90%). The IC50 values for complexes 14 were 19.54 2, 14.21 4, 12.43 4, and 12.43 4 M, respectively. Acridine orange (AO) and ethidium bromide (EtBr) staining and morphological analyses confirmed apoptosis as the primary mechanism of cell death, as evidenced by reduced adhesion, membrane blebbing, and cell rounding. The pronounced and selective cytotoxicity of these bromine-substituted Ru(ii) complexes highlights their potential as promising biomaterial candidates for targeted anticancer therapy. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique, 2026 Publisher An entity responsible for making the resource available Royal Society of Chemistry Relation A related resource ISSN: 11440546; CODEN: NJCHE Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online