Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Pakrashy, Sourav; Mandal, Prakash K.; Chakraborty, Souvik; Manna, Sounik; Arian, Tawsif Al; Choudhury, Sujata Maiti; Shinziya, Hazeena; Dolai, Malay; Das, Avijit Kumar Title A name given to the resource Investigation of the therapeutic potential of daphnetin, derived from Daucus carota leaves, against colorectal cancer: insights from in-silico, DFT, in-vitro, and fluorescence studies on its interactions with proteins Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Natural Product Research; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1080/14786419.2025.2592268" target="_blank" rel="noreferrer noopener">https://doi.org/10.1080/14786419.2025.2592268</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105022730427?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105022730427?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pakrashy S., Department of Chemistry, Prabhat Kumar College, Contai, India; Mandal P.K., Department of Chemistry, University of Calcutta, Kolkata, India; Chakraborty S., Department of Physiology, Bhairab Ganguly College, Kolkata, India; Manna S., Biochemistry, Molecular Endocrinology, and Reproductive Physiology Laboratory, Department of Human Physiology, Vidyasagar University, Midnapore, India; Arian T.A., Department of Pharmacy, Jahangirnagar University, Dhaka, Bangladesh; Choudhury S.M., Biochemistry, Molecular Endocrinology, and Reproductive Physiology Laboratory, Department of Human Physiology, Vidyasagar University, Midnapore, India; Shinziya H., Department of Chemistry, Christ University, Bangalore, India; Dolai M., Department of Chemistry, Prabhat Kumar College, Contai, India; Das A.K., Department of Chemistry, Christ University, Bangalore, India Description An account of the resource Daphnetin (NAP) has a sophisticated structure containing two oxygen-linked rings, which have long attracted medicinal chemists in the drug discovery process. Daphnetin features a coumarin structure with two hydroxy groups positioned side by side at the 7th and 8th carbons, making it an essential component for developing a novel triple point co-prodrug. We have isolated NAP from the leaves of Daucus carota (commonly known as carrot). NAP showed a good docking score with the EGFR protein obtained from network pharmacology, while molecular dynamics simulations evaluated the stability. ROS generation assays, MTT assays, etc. confirmed that NAP exhibits significant cytotoxic effects on HCT-116 cells. An investigation of the reverse phase interaction of NAP with BSA and ovalbumin, where proteins are added to the ligand solution, demonstrated fluorescence enhancement, ensuing in a observable colour transformation from neutral to blue, through binding-constants of 4.8 104 M?1 and 2.08 104 M?1. 2025 Informa UK Limited, trading as Taylor &amp; Francis Group. Subject The topic of the resource docking; intracellular ROS generation; Isolation; MD simulation; MTT assay; TDDFT Publisher An entity responsible for making the resource available Taylor and Francis Ltd. Relation A related resource ISSN: 14786419; CODEN: NPRAA Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Green Open Access Format The file format, physical medium, or dimensions of the resource online