Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Jain, Dhyanendra; Upreti, Kamal; Tak, Tan Kuan; Date, Saroj S.; Kshirsagar, Pravin R.; Jain, Rituraj; Agrawal, Rashmi Title A name given to the resource Predicting and Optimizing Synergistic Drug Combinations for Breast Cancer Treatment Using Machine Learning Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived American Journal of Clinical Oncology: Cancer Clinical Trials;Volume;49;Issue;3;pp.113-124 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1097/COC.0000000000001244" target="_blank" rel="noreferrer noopener">https://doi.org/10.1097/COC.0000000000001244</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105012555411?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105012555411?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jain D., Department of CSE-AIML, ABES Engineering College, Ghaziabad; Upreti K., CHRIST (Deemed to be University), Delhi NCR, Uttar Pradesh, Ghaziabad; Tak T.K., Singapore Institute of Technology, Singapore; Date S.S., CSMSS Chh. Shahu College of Engineering, Chh. Sambhajinagar, Aurangabad; Kshirsagar P.R., J D College of Engineering &amp; Management, Nagpur, Maharashtra, United States; Jain R., Department of Information Technology, Marwadi University, Gujarat, Rajkot; Agrawal R., Manav Rachna International Institute of Research and Studies, Haryana, Faridabad, India Description An account of the resource Objectives: The study aims to identify highly synergistic drug combinations for breast cancer treatment using machine learning models. The primary objective is to predict drug synergy scores accurately and rank combinations with the highest potential for therapeutic efficacy. Methods: Machine learning models, including XGBoost, Random Forest (RF), and CatBoost (CB), were employed to analyze breast cancer drug combination data. Four synergy metricsZIP, Bliss, Loewe, and HSAwere used to quantify drug interaction effects. The models were trained to predict these synergy scores, and their performance was evaluated using normalized root mean squared error (NRMSE) and Pearson correlation coefficient. Predicted top-ranking drug combinations were further validated by comparing observed versus expected dose-response curves and calculating the area under the curve (AUC) for synergy assessment. Results: XGBoost (XGB_5235) outperformed other models, achieving an NRMSE of 0.074 and a Pearson correlation of 0.90 for the Bliss synergy model. Based on average synergy scores, the top 20 drug combinations were identified, with Ixabepilone+Cladribine, SN 38 Lactone+Pazopanib, and Decitabine+Tretinoin emerging as the most promising. These combinations showed high synergy and were supported by biological insights into their mechanisms of action. Conclusions: The study demonstrates the effectiveness of machine learning in predicting synergistic drug combinations for breast cancer. By accelerating the screening process and reducing experimental burden, the approach offers a promising tool for guiding future in vitro and in vivo validation of combination therapies. Copyright 2025 Wolters Kluwer Health, Inc. All rights reserved. Subject The topic of the resource breast cancer; cell lines; drug discovery; machine learning; prediction; synergy metrics Publisher An entity responsible for making the resource available Lippincott Williams and Wilkins Relation A related resource ISSN: 2773732; CODEN: AJCOD Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online