ItemArticle

The Impact of Helicobacter Pylori Infection on Renal and Hepatic Function Parameters in Saudi Arabia, A Case-Control Study

Title
The Impact of Helicobacter Pylori Infection on Renal and Hepatic Function Parameters in Saudi Arabia, A Case-Control Study
Creator
Mahmoud, Madyha Hassan; Upreti, Kamal; Jeraiby, Mohammed Abdullah; Jain, Rituraj; Mjery, Yahia; Alnajai, Mahdi Mohammed; Otaif, Fozia Siddiq; Alam, Mohammad Shane
Description
Helicobacter pylori (H. pylori) is a common gastric pathogen that is linked to peptic ulcers, gastric cancer and systemic disorders. There is emerging evidence of an association between infection with H. pylori and chronic kidney disease and non-alcoholic hepatic steatosis, and possible renal and hepatic involvement. This study was conducted to assess the relationship between H. pylori and kidney and liver function changes in Saudi Arabian people. Blood samples were collected from 82 participants divided into two groups, namely H. pylori-infected and non-infected. Biochemical analyses were done to determine kidney (creatinine, urea, sodium and potassium) and liver function (ALT, AST, ALP, total protein and albumin). A total of 82 participants were included in the study, of whom 42 (51.2%) tested positive for Helicobacter pylori infection, while 40 (48.8%) were non-infected and served as the control group. Liver enzyme levels (ALP (64.00), AST (21.40), ALT (21.26) and GGT (20.78)) were normal and did not differ significantly between groups (p > 0.05). Regression analysis showed a significant relationship between H. pylori infection and high creatinine (OR = 6.38, p = 0.018). Borderline correlations were found for GGT (OR = 1.179, p = 0.092), uric acid (OR = 2.661, p = 0.061), and the electrolytes and lipid profiles showed no significant variation. H. pylori infection was significantly related to elevated creatinine levels, and may be affecting renal function. Most liver and electrolyte parameters were not affected. Further studies with larger cohorts are required in order to confirm these findings. Oriental Scientific Publishing Company 2026.
Source
Biomedical and Pharmacology Journal;Volume;19;Issue;1;pp.683-693
Date
01-01-2026
Publisher
Oriental Scientific Publishing Company
Subject
Gastric infection; Helicobacter pylori; Kidney function test; Liver function test; Non-alcoholic fatty liver disease
Coverage
Mahmoud M.H., Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia; Upreti K., Department of Computer Science, Christ University, Delhi NCR Campus, Ghaziabad, India; Jeraiby M.A., Department of Basic Medical Science, College of Medicine, Jazan University, Jazan, Saudi Arabia; Jain R., Department of Information Technology, Marwadi University, Gujarat, Rajkot, India; Mjery Y., Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia; Alnajai M.M., Laboratory Department, Jazan University Hospital, Jazan University, Jazan, Saudi Arabia; Otaif F.S., Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia; Alam M.S., Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia
Rights
All Open Access; Gold Open Access
Relation
ISSN: 9746242;
Format
online
Language
English
Type
Article

Citation

Mahmoud, Madyha Hassan; Upreti, Kamal; Jeraiby, Mohammed Abdullah; Jain, Rituraj; Mjery, Yahia; Alnajai, Mahdi Mohammed; Otaif, Fozia Siddiq; Alam, Mohammad Shane, “The Impact of Helicobacter Pylori Infection on Renal and Hepatic Function Parameters in Saudi Arabia, A Case-Control Study,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/23224.

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