ItemArticle

An exposition on complete androgen insensitivity syndrome and a case report; [??????? ?????? ?????????????????? ? ??????????: ??????????? ??????]

Title
An exposition on complete androgen insensitivity syndrome and a case report; [??????? ?????? ?????????????????? ? ??????????: ??????????? ??????]
Creator
Morkos, Simon; Al Qasem, Malek; Aldam, Mustafa; Bhotla, Haripriya Kuchi; Meyyazhagan, Arun; Pappuswamy, Manikantan; Iskandarani, Fadi; Kouteich, Khaled; Asoliman, Ahmed
Description
Complete androgen insensitivity syndrome (CAIS) is a rare X-linked sexual development condition typified by 46,XY karyotype, presence of external female genitalia along with intra-abdominal testes in labia majora or inguinal ring region. This syndrome results from alterations in the androgen receptor (AR) gene leading to primary amenorrhea and uterine agenesis (Mlerian agenesis) in adolescent teens or two-sided labial/inguinal hernia with testes in children around prepubertal age. Our paper reports a case of CAIS in a 16-year-old woman with no menarche and 46,XY karyotyping. Gonadectomy results showed hyperplasia of Leydig cells. The current research encompasses the case report and the available knowledge to date on the understanding, diagnosis, treatment, and management of CAIS. 2025 IRBIS LLC. All rights reserved.
Source
Obstetrics, Gynecology and Reproduction;Volume;19;Issue;1;pp.127-135
Date
01-01-2025
Publisher
IRBIS LLC
Subject
46; androgen receptor; AR; CAIS; case report; complete androgen insensitivity syndrome; gonads; hormone replacement therapy; XY
Coverage
Morkos S., Al Zahra Hospital, Al Barsha, Khadaek Mohammed Bin Rashid, Dubai, United Arab Emirates; Al Qasem M., Mutah University, Al Karak, 61710, Jordan; Aldam M., Healia Medical Center, Dubai, United Arab Emirates; Bhotla H.K., CHRIST (Deemed to be University), Karnataka, Bengaluru, 560029, India; Meyyazhagan A., CHRIST (Deemed to be University), Karnataka, Bengaluru, 560029, India; Pappuswamy M., CHRIST (Deemed to be University), Karnataka, Bengaluru, 560029, India; Iskandarani F., Al Zahra Hospital, Al Barsha, Khadaek Mohammed Bin Rashid, Dubai, United Arab Emirates; Kouteich K., Al Zahra Hospital, Al Barsha, Khadaek Mohammed Bin Rashid, Dubai, United Arab Emirates; Asoliman A., Al Zahra Hospital, Al Barsha, Khadaek Mohammed Bin Rashid, Dubai, United Arab Emirates
Rights
All Open Access; Gold Open Access; Green Open Access
Relation
ISSN: 23137347;
Format
online
Language
English
Type
Article

Citation

Morkos, Simon; Al Qasem, Malek; Aldam, Mustafa; Bhotla, Haripriya Kuchi; Meyyazhagan, Arun; Pappuswamy, Manikantan; Iskandarani, Fadi; Kouteich, Khaled; Asoliman, Ahmed, “An exposition on complete androgen insensitivity syndrome and a case report; [??????? ?????? ?????????????????? ? ??????????: ??????????? ??????],” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/23357.

Output Formats