Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Lakshman, Priyanka; Mayegowda, Shilpa Borehalli; Gadilingappa, Manjula Nagalapur Title A name given to the resource Extended-spectrum ?-Lactamase (ESBL) Producing Bacterial Pathogens Associated with Respiratory Tract Infections Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology;Volume;19;Issue;1;pp.601-616 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.22207/JPAM.19.1.50" target="_blank" rel="noreferrer noopener">https://doi.org/10.22207/JPAM.19.1.50</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105000467402?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105000467402?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Lakshman P., Department of Microbiology, School of Basic and Applied Sciences, Dayananda Sagar University, Bengaluru, India; Mayegowda S.B., School of Psychological Sciences, CHRIST University, Kengeri Campus, Bengaluru, India; Gadilingappa M.N., Department of Microbiology, School of Basic and Applied Sciences, Dayananda Sagar University, Bengaluru, India Description An account of the resource Respiratory tract infections (RTIs) have been critically associated with health care problems globally. Subsequently, increased antibiotic resistance rates have limited treatment options that are further exaggerated due to lack of newer novel drugs and therapies. Current study highlights, antibiotic resistance profiling along with extended-spectrum beta-lactamase (ESBL) producers of RTI pathogens from Bengaluru. During June 2020-May 2021, 1016 clinical samples collected, prevalence rate of 22.4% was exhibited, with highest in male (74.5%). Following age group, 30-35 years displayed highest (24.1%) though, lowest was in 45-50 years (1.3%). The standard microbiological characterization revealed Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii as predominant bacterial pathogens associated with RTIs. While, Antibiotic susceptibility test (AST) exhibited highest resistance rates for different antibiotics in the following pathogens, as K. pneumoniae for ampicillin (74.8%), P. aeruginosa for doripenem (66.6%), A baumannii to piperacillin/tazobactam (76.9%), E. coli for penicillin and ?-lactamase inhibitors ranging between 56-92%, E. cloacae to ticarcillin/clavulanic acid besides cefuroxime (100%). However, prevalence of Gram-positive strains were lowest and exhibited highest resistance to penicillin, and fluoroquinolone (83.3%). ESBL producers were predominantly K. pneumoniae, followed by E. coli, and E. cloacae with 21.9%, 6.5% and 1.3%, respectively. Notably, all the Gram-negative strains showed 100% sensitivity towards colistin with remarkable sensitivity was observed in oxazolidinone, glycopeptides by S. aureus and Coagulase-neagtive Staphylococcus aureus (CoNS). The study emphasizes increased antimicrobial resistance antimicrobial and ESBL resistance, suggesting AST as a systematic approach for apprising treatment guidelines in current scenario. The present study denotes polypeptide colistin as choice of drugs for treating RTI pathogens, however its not recommended in all cases. The Author(s) 2025. Subject The topic of the resource Antibiotic Resistance; Colistin; Extended-spectrum beta-lactamase; Respiratory Tract Infections Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Relation A related resource ISSN: 9737510; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Format The file format, physical medium, or dimensions of the resource online