ItemArticle

Phytochemicals in Lemongrass (Cymbopogon citratus) Contributing to Growth and Disease Resistance in Goldfish (Carassius auratus Linn. 1758): Integration of Molecular Docking and Statistical Analyses

Title
Phytochemicals in Lemongrass (Cymbopogon citratus) Contributing to Growth and Disease Resistance in Goldfish (Carassius auratus Linn. 1758): Integration of Molecular Docking and Statistical Analyses
Creator
Kappi, Valappil Anagha; Suma, Sarojini
Description
The ornamental fish industry has experienced significant growth with species like goldfish (Carassius auratus) gaining popularity for their vibrant appearance and ease of care. However, bacterial infections, particularly those caused by Aeromonas hydrophila, pose a significant threat to fish health and market value. In this study, visibly diseased goldfish exhibiting symptoms such as fin rot, black spots, tail rotting and skin lesions were divided into control and treated groups. The treated group was fed lemongrass (Cymbopogon citratus)-coated pellets, while the control group received standard feed. Over a three-week trial, visual improvements, including the healing of fin rot were documented, demonstrating the effectiveness of lemongrass-enhanced feed in promoting recovery and growth. GC-MS analysis of fresh lemongrass leaves identified key bioactive compounds, including citral, tetra decanoic acid, trans-verbenol and 1-undecanol, known for their antimicrobial properties. These findings confirmed the presence of phytochemicals with potential therapeutic applications against bacterial infections. Molecular docking studies further evaluated the interactions of prominent lemongrass phytochemicals: Procyanidin B2, Diosmin, Catechin and Tricin, with A. hydrophila outer membrane protein (3OD9). The results demonstrated strong binding affinities with Procyanidin B2 showing the highest (-8.0 kcal/mol), followed by Diosmin (-7.8 kcal/mol), Catechin (-7.6 kcal/mol) and Tricin (-7.6 kcal/mol), indicating their potential to inhibit bacterial pathogenicity. This study highlights the dual role of lemongrass as a natural growth promoter and antibacterial agent, emphasizing its potential as a sustainable and eco-friendly alternative to antibiotics in aquaculture. By effectively managing bacterial infections and improving fish health, lemongrass offers a promising solution for enhancing sustainability in aquaculture. 2026, World Researchers Associations. All rights reserved.
Source
Research Journal of Biotechnology;Volume;21;Issue;4;pp.173-181
Date
01-01-2026
Publisher
World Researchers Associations
Subject
GC-MS analysis; Goldfish; Lemon grass; Molecular docking
Coverage
Kappi V.A., Department of Life Sciences, CHRIST University, Bangalore, 560 029, India; Suma S., Department of Life Sciences, CHRIST University, Bangalore, 560 029, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 9736263;
Format
online
Language
English
Type
Article

Citation

Kappi, Valappil Anagha; Suma, Sarojini, “Phytochemicals in Lemongrass (Cymbopogon citratus) Contributing to Growth and Disease Resistance in Goldfish (Carassius auratus Linn. 1758): Integration of Molecular Docking and Statistical Analyses,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/23434.

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