Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource George, Jincy A.; Antony, Febin; Sridharan, Upasana; Paari, Kuppusamy Alagesan Title A name given to the resource Computational identification of microbial metabolites as potential inhibitors of mosquito juvenile hormone binding protein for vector control Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Journal of Applied and Natural Science;Volume;17;Issue;3;pp.1202-1213 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.31018/jans.v17i3.6699" target="_blank" rel="noreferrer noopener">https://doi.org/10.31018/jans.v17i3.6699</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105017436370?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105017436370?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant George J.A., Department of Zoology, St. Josephs University, Bengaluru, India; Antony F., Department of Computer Science, Westford University College, Sharjah, United Arab Emirates; Sridharan U., Department of Chemistry, University of California, Davis, CA, United States; Paari K.A., Department of Life Science, CHRIST (Deemed to be University), Bangalore, India Description An account of the resource A group of acyclic sesquiterpenoids, that form the Juvenile hormone is crucial in the developmental physiology of insects. Aedes aegypti is crucial in spreading fatal diseases such as dengue, and dengue hemorrhagic fever. The mosquito undergoes several stages of development, from the egg to the adult stage, utilizing its innate immunity system and juvenile hormone proteins. Thus, targeting the juvenile hormone-binding proteins can potentially inhibit the developmental stages of the mosquito. The mosquito juvenile hormone binding protein (mJHBP) of Aedes aegypti was obtained from the RCSB (PDB). The study identified that Talaromyces islandicus and Bacillus velezensis produced secondary metabolites that act as efficient ligand complexes. The secondary metabolites were procured from PubChem and docked to the binding sites of mJHBP. Among the 26 listed ligand compounds, oxalic acid, decyl 3,5-difluorophenyl ester, oxalic acid 3,5-difluorophenyl undecyl ester, and poctylacetophenone were found to have higher binding affinity, marking their efficiency in inhibiting the protein. Normal mode analysis studies were performed using iMODs to analyze the B-factor, variance, covariance, and Eigenvalues of the docked protein-ligand complexes. The Absorption, Distribution, Metabolism and Excretion (ADME) properties of the efficient ligand molecules were analyzed using the Swiss ADME tool to segregate potential drug candidates. Targeting the mJHBP complex using the microbial metabolite ligand molecules can inhibit the development of the mosquitoes. The work enlightens the futuristic development of potential candidates in the production of insecticides. The literature confirms it is the first of its type to utilize microbial bio compounds as ligands targeting the mJHB protein complex. : Author (s). Publishing rights @ ANSF. Subject The topic of the resource ADME analysis; Bacillus velezensis; Juvenile hormone binding protein; microbial metabolites; molecular docking; Talaromyces islandicus Publisher An entity responsible for making the resource available Applied and Natural Science Foundation Relation A related resource ISSN: 9749411; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Format The file format, physical medium, or dimensions of the resource online