CONTINUOUS FLOW TERPENE SYNTHESIS: METAL PLATE REACTOR-ENABLED DIELS-ALDER REACTIONS

Title

CONTINUOUS FLOW TERPENE SYNTHESIS: METAL PLATE REACTOR-ENABLED DIELS-ALDER REACTIONS

Creator

Imam, Kopparapu; Binish, C.J.; Vijayasankar, A.V.

Description

This study presents an eco-friendly, high-efficiency protocol for the industrial production of terpenes using a continuous flow process with metal plate reactors. Traditional methods like batch processing for terpene production via the Diels-Alder reaction suffer from low efficiency, high waste disposal, and high costs due to stringent requirements. In the current study, the reaction parameters were optimized in a continuous flow setup, focusing on conversion, selectivity, and waste reduction to enhance economic viability. The results of optimization studies demonstrate that reaction completion is attainable at temperatures of 90C and above, under conditions of 4 bar pressure, 1.05 mole equivalents of methyl pentenone, and 0.05 mol% % catalyst loading. The usage of polar solvents was found to adversely affect reagent conversion efficiency. The protocol was validated by comparison with batch methods and demonstrated reproducibility and scalability through a 24-hour continuous process, achieving a 95% mole yield and 96% conversion under optimized conditions. Analyses of Gas chromatography, GC-MS,1 H-and13 C-NMR were used to confirm the products. The findings support the industrial potential of the protocol for sustainable terpene production, reducing polymerization and minimizing by-products. 2025, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.

Source

Rasayan Journal of Chemistry;Volume;18;Issue;3;pp.1564-1573

Date

01-01-2025

Publisher

Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma

Subject

Continuous Flow Process; Diels-Alder Reactions; Flavour and Fragrances Molecules; Metal Plate Reactors; Terpenes

Coverage

Imam K., Department of Chemistry, Christ University, Karnataka, Bangalore, 560029, India; Binish C.J., Department of Chemistry, Christ University, Karnataka, Bangalore, 560029, India; Vijayasankar A.V., Department of Chemistry, Christ University, Karnataka, Bangalore, 560029, India

Rights

All Open Access; Gold Open Access

Relation

ISSN: 9741496;

Format

online

Language

English

Type

Article

Identifier

https://doi.org/10.31788/RJC.2025.1839289

https://www.scopus.com/pages/publications/105012390910?origin=resultslist