ItemArticle

Study of Expression of MST3 in Myeloid Leukaemia

Title
Study of Expression of MST3 in Myeloid Leukaemia
Creator
Arthi, Boro; Sujatha, Krishnaswamy; Gopal, Sridhar; Balamuralikrishnan, Balasubramanian; Arun, Meyyazhagan; Manikantan, Pappuswamy; Sampathkumar, Palanisamy; Anand, Arumugam Vijaya
Description
Myeloid leukaemia (ML) is a cancer that occurs by the accumulation of abnormally multiplied myeloid cells in bone marrow, peripheral blood, and other related tissue. MST3 is a gene of the GCK family that has a role in apoptosis, along with other cellular functions like cellular differentiation, cell cycle, metabolism, and others. Objectives: The objectives of this study were to count RBCs and WBCs, study MST3 expression in ML and control samples, and perform an in silico correlation study on the KRAS and NRAS genes. Methods: The counting of RBCs and WBCs was carried out using a hemacytometer, the expression of MST3 was studied using RT-PCR, and a correlation study was carried out using GEPIA. Results: RBC and WBC levels in ML differed from the control levels, and the expression of MST3 was found to be upregulated in ML in comparison to controls, with a 2.908.65-fold change, with a significant p-value > 0.05. A positive correlation in expression was also found between MST3 and KRAS and NRAS genes, with a significant r value correlation. Conclusions: From this study, it could be deduced that MST3 might have a role in ML pathogenesis, but further research is needed to study its role in the progression of the disease. 2025 by the authors.
Source
Medical sciences;Volume;13;Issue;2;Article No.;33;
Date
01-01-2025
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Subject
blood cell counting; correlation; expression; MST3; myeloid leukaemia
Coverage
Arthi B., Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641046, India; Sujatha K., Department of Zoology, Government Arts College, Coimbatore, 641018, India; Gopal S., Sri Ramakrishna Hospital, 395, Sarojini Naidu Road, Siddhapudur, Coimbatore, 641044, India; Balamuralikrishnan B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Arun M., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560029, India; Manikantan P., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560029, India; Sampathkumar P., Department of Chemistry and Biosciences, SASTRA (Shanmugha Arts, Science, Technology & Research Academy) Deemed to be University, Srinivasa Ramanujan Centre, Kumbakonam, 612001, India; Anand A.V., Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641046, India
Rights
All Open Access; Gold Open Access; Green Open Access
Relation
ISSN: 20763271;
Format
online
Language
English
Type
Article

Citation

Arthi, Boro; Sujatha, Krishnaswamy; Gopal, Sridhar; Balamuralikrishnan, Balasubramanian; Arun, Meyyazhagan; Manikantan, Pappuswamy; Sampathkumar, Palanisamy; Anand, Arumugam Vijaya, “Study of Expression of MST3 in Myeloid Leukaemia,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/23535.

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