Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Kumari, Sonit; Malviya, Alok Kumar Title A name given to the resource Evaluating the Potential of Cordycepin as a Therapeutic Agent for Cancer: In-Silico Analysis of EGFR and VEGFR Interactions Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived International Research Journal of Multidisciplinary Scope;Volume;6;Issue;2;pp.1103-1111 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.47857/irjms.2025.v06i02.03710" target="_blank" rel="noreferrer noopener">https://doi.org/10.47857/irjms.2025.v06i02.03710</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105006710346?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105006710346?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Kumari S., Applied and Industrial Biotechnology Laboratory, Department of Life Sciences, CHRIST (Deemed-to-Be University), Karnataka, Bangalore, India; Malviya A.K., Applied and Industrial Biotechnology Laboratory, Department of Life Sciences, CHRIST (Deemed-to-Be University), Karnataka, Bangalore, India Description An account of the resource Due to multipotent activity, Cordycepin, a nucleoside isolated from Cordyceps fungi (Cordyceps militaris), has recently attracted considerable interest as a compound for antitumor. Cordycepin is also known as 3-deoxyadenosine, which is known to inhibit tumor growth, but the actual mechanism is not known. The present work aims to evaluate the cordycepin as an anticancer candidate by analyzing its impact on the major oncogene receptors EGFR and VEGFR through an in-silico approach. In the analysis, computational docking was performed with AutoDock Vina 1.5.7, which estimated the binding constants of cordycepin with EGFR and VEGFR and got binding energies of -6.8 kcal/mol and -5.5 kcal/mol, respectively, relative to a reference Leucovorin molecule. In addition, molecular dynamics simulations were also performed for the best complex (Cordycepin-EGFR) to examine the conformational dynamic behavior of the cordycepin-EGFR complex. The functionality and architecture of the cordycepin-EGFR complex were illustrated: their interaction might serve as a base for therapy. Also, ADMET predictions show that cordycepin follows Lipinskis rules, which supports the drug-likeness of cordycepin compounds. Accordingly, the findings presented here will confirm and draw the attention of the scientific community to use the cordycepin as a possible treatment for cancer and its potential use in scientific pharmacology. 2025, Iquz Galaxy Publisher. All rights reserved. Subject The topic of the resource ADMET; Cordycepin; EGFR; Molecular Docking; Molecular Dynamic Simulation; VEGFR Publisher An entity responsible for making the resource available Iquz Galaxy Publisher Relation A related resource ISSN: 2582631X; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access Format The file format, physical medium, or dimensions of the resource online