Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Anuja., V.; Rangaswamy, Rashmi; Shukla, Priyanka; Das, Papri; Prabavathy, M.; Lodha, Niraj Title A name given to the resource Cognitive Behavioral Therapy for Tinnitus: An Applied Bioanalytical Perspective Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Journal of Applied Bioanalysis;Volume;11;Issue;4;pp.1077-1084 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.53555/jab.v11i4.479" target="_blank" rel="noreferrer noopener">https://doi.org/10.53555/jab.v11i4.479</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105015397911?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105015397911?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Anuja. V., S. A. Collage of Arts &amp; Science Chennai, Tamil Nadu, India; Rangaswamy R., Christ University, India; Shukla P., School of Arts, Humanities &amp; Social Sciences, CSJMU, Kanpur, India; Das P., Institute of Nursing, Brainware University, West Bengal, India; Prabavathy M., Centre for Differently Abled Persons Bharathidasan University, Tamil Nadu, India; Lodha N., Lodha Hospital and Research Centre, Rajasthan, Pali, India Description An account of the resource Tinnitus affects 1015% of adults worldwide, with 23% experiencing severe and chronic symptoms that impair quality of life. Conventional treatments often provide limited long-term relief, while Cognitive Behavioral Therapy (CBT) has emerged as an evidence-based intervention. The present study evaluated the effectiveness of CBT for tinnitus through an integrated psychometric and bioanalytical approach. A total of 100 participants were randomized into a CBT group (n = 50) and a waitlist control group (n = 50). The CBT program consisted of 12 weekly sessions delivered over 12 weeks. Psychometric assessments included the Tinnitus Handicap Inventory (THI), Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index (PSQI), and WHOQOL-BREF. Bioanalytical measures comprised functional MRI, EEG, salivary cortisol, heart rate variability (HRV), and inflammatory cytokines (IL-6, TNF-?). The CBT group achieved a 45% reduction in THI scores (58.4 9.2 to 32.1 8.5), while the control group showed only a 5% change. Anxiety and depression scores decreased by 42% and 40%, respectively, and sleep quality improved by 38%. Morning cortisol increased by 48%, HRV improved by 38%, and inflammatory cytokines decreased significantly (IL-6: ?26%; TNF-?: ?19%). Neuroimaging and EEG findings confirmed reduced auditory cortex hyperactivity and abnormal connectivity. These results demonstrate that CBT not only alleviates tinnitus distress but also induces measurable neurophysiological and systemic changes, reinforcing its role as a cornerstone of evidence-based tinnitus management. 2025, Green Publication. All rights reserved. Subject The topic of the resource Biomarkers; Cognitive Behavioral Therapy; Neuroimaging; Psychometrics; Tinnitus Publisher An entity responsible for making the resource available Green Publication Relation A related resource ISSN: 2405710X; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access Format The file format, physical medium, or dimensions of the resource online