Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Harshitha, K.R.; Xavier, Jobi Title A name given to the resource Anticancer potential of Ipomoea alba: Induction of apoptosis and cell cycle arrest in MDA-MB-231 cells Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Medicinal Plants;Volume;17;Issue;3;pp.510-517 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.5958/0975-6892.2025.00052.5" target="_blank" rel="noreferrer noopener">https://doi.org/10.5958/0975-6892.2025.00052.5</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105024195917?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105024195917?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Harshitha K.R., Department of Life Science, Christ (Deemed to be University), Karnataka, Bangalore, 560029, India; Xavier J., Department of Life Science, Christ (Deemed to be University), Karnataka, Bangalore, 560029, India Description An account of the resource Cancer is one of the major global health concerns, which supports the investigation of novel therapeutic agents with enhanced potency and minimal side effects. Ipomoea alba, belonging to the Convolvulaceae family, was selected for this study due to its known anti-inflammatory properties and the presence of secondary medical applicability. In this study, the cytotoxic, apoptotic, and cell cycle arrest effects of the methanol extract of Ipomoea alba were evaluated against MDA-MB-231 human breast cancer cell lines. Cytotoxicity was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay across varying concentrations, revealing an IC50 value of 167.02 g/mL after 24 hours of treatment. Apoptosis and necrosis were examined through Annexin V/propidium iodide (PI) staining via flow cytometry, with treated cells showing 58.1% apoptosis (p &lt; 0.001) and 16.71% necrosis (p &lt; 0.01) compared to the control. Cell cycle distribution, evaluated using PI/ribonuclease (RNase) staining, revealed a significant increase in the G2 /M phase (56.31%, p &lt; 0.001) and a mild increase in the Sub G0 /G1 phase (1.12%, p &lt; 0.05), indicating arrest at critical regulatory checkpoints. These findings demonstrate that I. alba methanol extract possesses potent anticancer properties by inducing apoptosis and interfering with cell cycle progression in breast cancer cells. The results suggest its potential as a candidate for anticancer drug development and alternative therapeutic strategies. 2025, Indian journals. All rights reserved. Subject The topic of the resource Anticancer activity; apoptosis; breast cancer; cell cycle arrest; cytotoxicity; Ipomoea alba; MDA-MB-231; methanol extract Publisher An entity responsible for making the resource available Indian journals Relation A related resource ISSN: 9754261; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online