ItemBook Chapter

Cardiac Endothelial Impairment in the Danio Rerio Due to Change in the Circadian Rhythm

Title
Cardiac Endothelial Impairment in the Danio Rerio Due to Change in the Circadian Rhythm
Creator
Dyapanagoudar, Pooja; Tomson, Majesh
Description
Light is one of the environmental factors which regulates the circadian rhythm in humans and animals. Circadian rhythm is a light and dark cycle which controls awakeness and sleepiness. Circadian rhythm regulates all the physiological functions. Artificial light at night disrupts the circadian rhythm in the population. Mostly developing and developed country population is very much prone to the disturbance in the circadian rhythm as shift work becomes very common. In this study we have disturbed the circadian rhythm of the Danio rerio by continuously exposing them to bright light and disturbing their resting period by creating surface waves for 96 h. At regular intervals, triplicates were meticulously extracted from control and experimental tanks, their hearts tenderly dissected and preserved in formaldehyde for subsequent analysis. Through the lens of a microtome, the intricate architecture of cardiac tissue unveiled a disquieting narrative, after 48 h and 72 h show trabeculae and necrosis in the inner layer of the ventricles and lumens were seen in the bulbus arteriosus. These findings not only mirror the cardiac consequences observed in humans experiencing circadian disruptions but also underscore the potential of zebrafish as valuable models for investigating pharmacological interventions aimed at mitigating such cardiovascular consequences. The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.
Source
Springer Proceedings in Earth and Environmental Sciences;Volume;Part F999;pp.865-873
Date
01-01-2025
Publisher
Springer Nature
Subject
Artificial Light; Cardiac endothelial impairment; Circadian Rhythm; Melatonin
Coverage
Dyapanagoudar P., Christ University, Karnataka, Bengaluru, 560029, India; Tomson M., Christ University, Karnataka, Bengaluru, 560029, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 2524342X;
Format
online
Language
English
Type
Book chapter

Citation

Dyapanagoudar, Pooja; Tomson, Majesh, “Cardiac Endothelial Impairment in the Danio Rerio Due to Change in the Circadian Rhythm,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 19, 2026, https://archives.christuniversity.in/items/show/24045.

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