Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Book Chapter Faculty Publications- Book Chapter Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Gobinath, Mirunalini; Mukherjee, Sagarika; Almoselhy, Rania I. M.; Siddiqui, Mohd Aftab; Usmani, Afreen; Rajendran, Rajakumari; Thomas, Sabu; Bihani, Manisha Title A name given to the resource Synergism in Nutraceutical Formulations Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Handbook of Nutraceuticals: Science, Technology and Engineering;pp.625-648 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/978-3-031-98791-5_49" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/978-3-031-98791-5_49</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105032517310?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105032517310?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Gobinath M., Department of Pharmacognosy &amp; Phytopharmacy, JSS College of Pharmacy, JSS Academy of Higher Education &amp; Research, Tamil Nadu, Ooty, India; Mukherjee S., Department of Pharmacognosy &amp; Phytopharmacy, JSS College of Pharmacy, JSS Academy of Higher Education &amp; Research, Tamil Nadu, Ooty, India; Almoselhy R.I.M., Oils and Fats Research Department, Food Technology Research Institute, Agricultural Research Center, Giza, Egypt; Siddiqui M.A., Faculty of Pharmacy, Integral University, Uttar Pradesh, Lucknow, India; Usmani A., Department of Pharmacology, MESCO Institute of Pharmacy, Amroha, India; Rajendran R., The Oxford College of Pharmacy, Karnataka, Bengaluru, India; Thomas S., Center of Excellence in Polymeric Materials for Medical Practice Devices, Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand, TrEST Research Park, Kerala, Trivandrum, India, School of Nanoscience and Nanotechnology, Mahatma Gandhi University, Kerala, Kottayam, India, Department of Physics and Electronics, Christ University, Bangalore, India; Bihani M., Department of Pharmacognosy, Krupanidhi College of Pharmacy, Karnataka, Bangalore, India Description An account of the resource Nutraceuticals are bioactive compounds or functional foods consumed to sustain nutrition and support disease prevention. Derived from nutrition and pharmaceuticals, the concept merges food science with therapeutic potential. Synergism in nutraceutical formulations arises when two or more bioactive agents interact to produce enhanced pharmacological or physiological outcomes that surpass the sum of their individual effects. This principle addresses key challenges of monotherapy: poor bioavailability, limited target specificity, and rapid metabolic degradation by enabling multicomponent, mechanistically complementary formulations. Recent innovations such as nano-encapsulation and codelivery systems further enhance absorption, stability, and efficacy of synergistic blends. This chapter provides a comprehensive overview of molecular and formulation-based synergism in nutraceuticals, focusing on mechanistic interactions, formulation challenges, and future directions toward supernutraceuticals that integrate advanced bioengineering and traditional dietary wisdom. Springer Nature Switzerland AG 2026. Subject The topic of the resource Bioactive synergy; Bioavailability; Functional foods; Nanocarriers; Nutraceuticals; Pharmacokinetic enhancement Publisher An entity responsible for making the resource available Springer Nature Relation A related resource ISBN: 978-303198791-5; 978-303198790-8; Language A language of the resource English Type The nature or genre of the resource Book chapter Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online