Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Book Chapter Faculty Publications- Book Chapter Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Thakur, Ravi; Kumari, Niti Title A name given to the resource Targeting Metabolic Reprogramming: A New Frontier in Cancer Therapy Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Molecular Targets in Cancer Therapy: Understanding Cellular Pathways for Therapeutic Interventions;pp.201-226 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/978-981-96-7336-0_9" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/978-981-96-7336-0_9</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105022380284?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105022380284?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Thakur R., Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States, Department of Life Sciences, Christ University, Bengaluru, India; Kumari N., Biomedical Sciences Department, Creighton University School of Medicine, Omaha, NE, United States Description An account of the resource Cancer cells undergo profound metabolic reprogramming to meet the high demands of unchecked proliferation within the nutrient-limited tumor microenvironment (TME). While fundamental metabolic pathways are conserved, cancer cells exhibit distinct metabolic fluxes and substrate preferences, meticulously dictated by genetic, epigenetic, and microenvironmental cues that reshape enzyme and transporter profiles. This metabolic rewiring sculpts the TME, fostering both competition and cooperation, often favoring tumor-promoting stromal components (cancer-associated fibroblasts, M2 tumor-associated macrophages), and hinders antitumor immunity. Targeting aberrant cancer metabolism and originating interactions in TME presents a promising therapeutic avenue. However, the inherent metabolic heterogeneity across malignancies necessitates personalized combination therapies and continued research to efficiently target this key cancer hallmark. 2025 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. Subject The topic of the resource Cancer; Metabolic reprogramming; Metabolic targeting; Tumor microenvironment Publisher An entity responsible for making the resource available Springer Science+Business Media Relation A related resource ISBN: 978-981967336-0; 978-981967335-3; Language A language of the resource English Type The nature or genre of the resource Book chapter Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online