Novel synthesis and dft calculations of 3-PHENYL-2-(1H-TETRAZOL-5-YL)acrylamdes under catalyst-free, one-pot cascade reaction /
Title
Novel synthesis and dft calculations of 3-PHENYL-2-(1H-TETRAZOL-5-YL)acrylamdes under catalyst-free, one-pot cascade reaction /
Subject
Chemical
Description
Patent Number: 202141023459, Applicant: Jyothis Devasia.
The present invention offers a novel method for the synthesis of 3-phenyl-2-(1H-tetrazol-5-yl)acrylamides 4(a-g) under catalyst-free conditions. All the reactions were carried out in an one-pot cascade process starting with various aromatic/heteroaryl aldehydes, 2-cyanoacetamide and sodium azide at 110 oC using dimethylformamide (DMF) as a solvent. In addition, the reaction conditions were screened for optimization conditions towards solvent, catalyst, temperature and equivalence of sodium azide.
The present invention offers a novel method for the synthesis of 3-phenyl-2-(1H-tetrazol-5-yl)acrylamides 4(a-g) under catalyst-free conditions. All the reactions were carried out in an one-pot cascade process starting with various aromatic/heteroaryl aldehydes, 2-cyanoacetamide and sodium azide at 110 oC using dimethylformamide (DMF) as a solvent. In addition, the reaction conditions were screened for optimization conditions towards solvent, catalyst, temperature and equivalence of sodium azide.
Creator
Nizam, Aatika.
Publisher
Intellectual Property India
Date
2021
Language
English
Type
Patent
Collection
Citation
Nizam, Aatika., “Novel synthesis and dft calculations of 3-PHENYL-2-(1H-TETRAZOL-5-YL)acrylamdes under catalyst-free, one-pot cascade reaction /,” CHRIST (Deemed To Be University) Institutional Repository, accessed September 8, 2024, https://archives.christuniversity.in/items/show/2436.