Novel synthesis and dft calculations of 3-PHENYL-2-(1H-TETRAZOL-5-YL)acrylamdes under catalyst-free, one-pot cascade reaction /
- Title
- Novel synthesis and dft calculations of 3-PHENYL-2-(1H-TETRAZOL-5-YL)acrylamdes under catalyst-free, one-pot cascade reaction /
- Creator
- Nizam, Aatika.
- Description
- Patent Number: 202141023459, Applicant: Jyothis Devasia.
The present invention offers a novel method for the synthesis of 3-phenyl-2-(1H-tetrazol-5-yl)acrylamides 4(a-g) under catalyst-free conditions. All the reactions were carried out in an one-pot cascade process starting with various aromatic/heteroaryl aldehydes, 2-cyanoacetamide and sodium azide at 110 oC using dimethylformamide (DMF) as a solvent. In addition, the reaction conditions were screened for optimization conditions towards solvent, catalyst, temperature and equivalence of sodium azide. - Date
- 2021-03-29
- Publisher
- Intellectual Property India
- Subject
- Chemical
- Language
- English
- Type
- Patent
Files
Collection
Citation
Nizam, Aatika., “Novel synthesis and dft calculations of 3-PHENYL-2-(1H-TETRAZOL-5-YL)acrylamdes under catalyst-free, one-pot cascade reaction /,” CHRIST (Deemed To Be University) Institutional Repository, accessed March 14, 2025, https://archives.christuniversity.in/items/show/2436.