Neuroinflammation and cognitive function in infectious diseases

Title

Neuroinflammation and cognitive function in infectious diseases

Creator

Sathyamoorthy, Yogesh Kanna; Thirumoorthi, Vithya; Singha, Ranjit

Description

Inflammation of the central nervous system (CNS), which various infectious diseases can induce and significantly affect cognitive functions. The review enriches the current understanding of neuroinflammation pathology and suggests novel diagnostic/therapeutic strategies for cognitive impairments. Pathogens cause disruption of the blood-brain barrier (BBB), which could be due to a repertoire of mechanism viz. the interplay of inflammatory cytokines and reactive oxygen species. The influence of neuroinflammation on cognitive function is immense and multifactorial. Neuroinflammatory responses in the acute phase can result in cognitive impairments, like memory deficits, attention span being reduced, and executive dysfunction. However, in cases of persistent neuroinflammation lead to long-term cognitive decline and neurodegenerative processes. The mechanisms underlying these cognitive changes are diverse, including disruptions in synaptic plasticity, alterations in neurotransmitter systems, and neuronal cell death. 2025 by IGI Global Scientific Publishing. All rights reserved.

Source

Research Methodologies and Practical Applications in Psychoneuroimmunology;pp.195-218

Date

01-01-2025

Publisher

IGI Global

Coverage

Sathyamoorthy Y.K., Christ University, India; Thirumoorthi V., Al Ameen College of Pharmacy, India; Singha R., Christ University, India

Rights

Restricted Access; Hardcopy may be available in the library

Relation

ISBN: 979-836937434-4; 979-836937432-0;

Format

online

Language

English

Type

Book chapter

Identifier

https://doi.org/10.4018/979-8-3693-7432-0.ch010

https://www.scopus.com/pages/publications/105003191959?origin=resultslist