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                <text>Faculty Publications</text>
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              <text>Mayegowda, Shilpa Borehalli; Donni, Sacheth Kiran; Patnaik, Aditi; Prince, Kevin</text>
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              <text>Psychoneuroimmunology in the context of dementia</text>
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              <text>01-01-2025</text>
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              <text>Research Methodologies and Practical Applications in Psychoneuroimmunology;pp.293-321</text>
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              <text>&lt;a href="https://doi.org/10.4018/979-8-3693-7432-0.ch014" target="_blank" rel="noreferrer noopener"&gt;https://doi.org/10.4018/979-8-3693-7432-0.ch014&lt;/a&gt; &lt;br /&gt;&lt;br /&gt;&lt;a href="https://www.scopus.com/pages/publications/105003144553?origin=resultslist" target="_blank" rel="noreferrer noopener"&gt;https://www.scopus.com/pages/publications/105003144553?origin=resultslist&lt;/a&gt;</text>
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              <text>Mayegowda S.B., Christ University, India; Donni S.K., Christ University, India; Patnaik A., Christ University, India; Prince K., Christ University, India</text>
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              <text>Dementia is a neurodegenerative condition that affects a multitude of cognitive functions. This chapter delves into the vulnerabilities and risk factors associated with aging that can lead to dementia. Aging brings a higher risk of depression and anxiety. The chapter uses the framework of psychoneuroimmunology to explain how psychological states during old age and after the diagnosis of dementia result in immune consequences. The consequences of dementia on daily functioning result in disturbances in sleep, appetite, mobility, sociability, and overall activities of daily living. Impairments in these areas cause increased reliance on caregivers to fulfill daily needs. These disturbances are accompanied by an overactivation of the HPA axis, impairments in glial cell functioning, disturbed glucocorticoid and mineralocorticoid functioning, a compromised gut-brain axis, and an overall increase in the release of proinflammatory cytokines. These physiological changes consequently increase neuroinflammation accelerating the progression of dementia.  2025 by IGI Global Scientific Publishing. All rights reserved.</text>
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              <text>IGI Global</text>
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              <text>ISBN: 979-836937434-4; 979-836937432-0;</text>
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              <text>Restricted Access; Hardcopy may be available in the library</text>
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