Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Conference Paper Faculty Publications- Conference Papers Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Sivakumar, R.; Kirubanand, V.B.; Ganesan, V.; Sivaraman, M.; Kumarachelvan, A.; Ulaganathan, G. Title A name given to the resource Building Smarter Systems with Advanced Computational Techniques Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Proceedings of 8th International Conference on Inventive Computation Technologies, ICICT 2025;pp.772-777 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1109/ICICT64420.2025.11004665" target="_blank" rel="noreferrer noopener">https://doi.org/10.1109/ICICT64420.2025.11004665</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105007426760?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105007426760?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Sivakumar R., CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Kirubanand V.B., CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Ganesan V., Department of Computer Science, Dr.G.R.Damodaran College of Science, Tamilnadu, Coimbatore, India; Sivaraman M., Department of Computer Science, Karpagam Academy of Higher Education, Tamilnadu, Coimbatore, India; Kumarachelvan A., Department of Library and Information Science, Dr. SNS Rajalakshmi College of Arts and Science (Autonomous), Tamilnadu, Coimbatore, India; Ulaganathan G., Department of Library and Information Science, Dr. SNS Rajalakshmi College of Arts and Science (Autonomous), Tamilnadu, Coimbatore, India Description An account of the resource The biological data analysis is a key approach that uses the genetic, transcriptomics, proteomics, metabolomics, or clinical data to discover diseases. Diabetes and leukemia are two independent medical disorders, but research has found that people with type 2 diabetes have a 20% higher chance of developing blood malignancies such as acute leukemia, showing a link between the two. Early identification of these disorders by studying biological datasets is critical for providing prognostic information. However, the class imbalance and high dimensionality problems in Machine Learning (ML)based techniques have often degraded effective analysis of clinical and genomic datasets for disease detection. This paper focuses on developing an efficient clinical decision support system using advanced metaheuristic and ML algorithms to solve class imbalance and high dimensionality problems. The first stage of the proposed approach utilizes an optional data augmentation and another pre-processing method for outlier detection and removal using Modified Z-Score (MZS) based on the Median Absolute Deviation (MAD) metric. Then, the optimal features/genes are selected using a hybrid Firefly Pearson's Correlation Coefficient (FPCC)-based Feature/Gene Selection method to reduce the higher feature dimensionality problem. Once the features/genes are selected, the proposed Ladybug Beetle Optimized Universum Learning-based Twin Boosted Adaptive Support Vector Machine (LBO-ULTBASVM) classifier detects the disease with reduced model complexity and error rates. LBO-ULTBASVM is developed by improving the Twin Support Vector Machine (TSVM) classifier by integrating the Universum Learning, Ladybug Beetle Optimization (LBO), and XGBoost for solving the class imbalance problem, reducing training time and improving disease accuracy. Experiments are conducted using PIMA Indians Diabetes and GSE9476 Leukemia datasets and the outcomes indicated that the LBO-ULTBASVM-based model increases the diabetes and leukemia detection accuracy with reduced model complexity and processing time. 2025 IEEE. Subject The topic of the resource Biological data analysis; Diabetes; Firefly Pearson's Correlation Coefficient; Ladybug Beetle Optimization; Leukemia; Modified Z-Score; Twin Boosted Adaptive Support Vector Machine; Universum Learning Publisher An entity responsible for making the resource available Institute of Electrical and Electronics Engineers Inc. Relation A related resource ISBN: 979-833151224-8; Language A language of the resource English Type The nature or genre of the resource Conference paper Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online