Cardiac Endothelial Impairment in the Danio Rerio Due to Change in the Circadian Rhythm
subject: Artificial Light; Cardiac endothelial impairment; Circadian Rhythm; Melatonin
description: Light is one of the environmental factors which regulates the circadian rhythm in humans and animals. Circadian rhythm is a light and dark cycle which controls awakeness and sleepiness. Circadian rhythm regulates all the physiological functions. Artificial light at night disrupts the circadian rhythm in the population. Mostly developing and developed country population is very much prone to the disturbance in the circadian rhythm as shift work becomes very common. In this study we have disturbed the circadian rhythm of the Danio rerio by continuously exposing them to bright light and disturbing their resting period by creating surface waves for 96 h. At regular intervals, triplicates were meticulously extracted from control and experimental tanks, their hearts tenderly dissected and preserved in formaldehyde for subsequent analysis. Through the lens of a microtome, the intricate architecture of cardiac tissue unveiled a disquieting narrative, after 48 h and 72 h show trabeculae and necrosis in the inner layer of the ventricles and lumens were seen in the bulbus arteriosus. These findings not only mirror the cardiac consequences observed in humans experiencing circadian disruptions but also underscore the potential of zebrafish as valuable models for investigating pharmacological interventions aimed at mitigating such cardiovascular consequences. The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.
creator: Dyapanagoudar, Pooja; Tomson, Majesh
source: Springer Proceedings in Earth and Environmental Sciences;Volume;Part F999;pp.865-873
publisher: Springer Nature
date: 01-01-2025
rights: Restricted Access; Hardcopy may be available in the library
relation: ISSN: 2524342X;
language: English
type: Book chapter
coverage: Dyapanagoudar P., Christ University, Karnataka, Bengaluru, 560029, India; Tomson M., Christ University, Karnataka, Bengaluru, 560029, India