Pangenomics for developing viral disease-resistant plants: Harnessing synergenetic pangenomics for advanced viral disease resistance in crops
Agriculture and gene editing; Disease resistance; Food security; Pangenomics; Plant virus
Agriculture plays a pivotal role in the global economy, but it also faces several significant challenges. One major challenge is the necessity to sustainably provide food for a rapidly expanding population. Additionally, agriculture must withstand the threat of different disease-causing pathogens, including various microorganisms like bacteria, viruses, and fungi. Viral diseases significantly impact crop growth, vitality, and yields, posing substantial threats to global agriculture. Despite their compact genomes, the viruses still lead to major losses in crop production. The study of plant viruses began over a century ago with the tobacco mosaic virus discovery, marking the inception of plant virology. Since then, hundreds of viruses have been identified, many of which induce severe damage to various crops. Viruses exhibit extensive genetic diversity, with RNA serving as the predominant genetic material. This genetic diversity profoundly influences their reproductive cycles and lifestyles, necessitating innovative strategies for disease management. This chapter discusses different pathogenic viruses along with various approaches to pest management, including the emergence of pangenomics as one of the advanced tools for understanding the diversity of genes among plant populations. Pangenomics encompasses both function-based and structure-based approaches, elucidating the core and dispensable genomes that contribute to discovering many agronomic traits related to disease resistance mechanisms, crop yield, flowering time, etc. Integrating the information from pangenomics into plant virology can revolutionize agriculture by enhancing crop production and crop yield, and also engineering viral disease-resistant plants to ensure global food security. 2025 Elsevier Inc. All rights reserved.
Sahithi, Baru Venkata Naga; Sudheer, Wudali Narasimha; Lakshmaiah, Vasantha Veerappa; Al-Khayri, Jameel M; Nagella, Praveen
Plant Pangenomes and Pangenomics;pp.301-328
Restricted Access; Hardcopy may be available in the library
https://doi.org/10.1016/B978-0-443-26791-8.00015-7 https://www.scopus.com/pages/publications/105025872191?origin=resultslist
Sahithi B.V.N., Department of Life Sciences, School of Sciences, Christ University, Karnataka, Bengaluru, India; Sudheer W.N., Department of Life Sciences, School of Sciences, Christ University, Karnataka, Bengaluru, India; Lakshmaiah V.V., Department of Life Sciences, School of Sciences, Christ University, Karnataka, Bengaluru, India; Al-Khayri J.M., Department of Agricultural Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, Saudi Arabia; Nagella P., Department of Life Sciences, School of Sciences, Christ University, Karnataka, Bengaluru, India