Neuroinflammation and cognitive function in infectious diseases
Inflammation of the central nervous system (CNS), which various infectious diseases can induce and significantly affect cognitive functions. The review enriches the current understanding of neuroinflammation pathology and suggests novel diagnostic/therapeutic strategies for cognitive impairments. Pathogens cause disruption of the blood-brain barrier (BBB), which could be due to a repertoire of mechanism viz. the interplay of inflammatory cytokines and reactive oxygen species. The influence of neuroinflammation on cognitive function is immense and multifactorial. Neuroinflammatory responses in the acute phase can result in cognitive impairments, like memory deficits, attention span being reduced, and executive dysfunction. However, in cases of persistent neuroinflammation lead to long-term cognitive decline and neurodegenerative processes. The mechanisms underlying these cognitive changes are diverse, including disruptions in synaptic plasticity, alterations in neurotransmitter systems, and neuronal cell death. 2025 by IGI Global Scientific Publishing. All rights reserved.
Sathyamoorthy, Yogesh Kanna; Thirumoorthi, Vithya; Singha, Ranjit
Research Methodologies and Practical Applications in Psychoneuroimmunology;pp.195-218
Restricted Access; Hardcopy may be available in the library
https://doi.org/10.4018/979-8-3693-7432-0.ch010 https://www.scopus.com/pages/publications/105003191959?origin=resultslist
Sathyamoorthy Y.K., Christ University, India; Thirumoorthi V., Al Ameen College of Pharmacy, India; Singha R., Christ University, India