The enigmatic gut-brain-immune trio in brain and behavior disorders
The human gut is a bustling colony of micro-inhabitants such as bacteria, archaea, and eukarya. These microbes inhabited the earth trillions of years before humans, evolved along with humans, and have now outnumbered humans. It has now been established without doubt that these microbiota within us play a significant role in the maintenance of our physical health. They exist in a symbiotic and/or commensal relationship within the host body and assist in digestion, metabolism, and regulation of the immune functions. Interestingly, recent reports suggest that these aliens can regulated our brain and behaviour too. The role of the gut-brain axis in the overall well-being is becoming increasingly evident and nurturing this connection might address many of the challenges in targeting illnesses of the brain. Moreover, in the wake of the COVID-19 pandemic, more and more evidences have unfolded suggesting the impact of peripheral inflammation on mental health. Here, the importance of gut microbes, peripheral immune system, and their influence on brain diseases is addressed. 2025 by IGI Global Scientific Publishing. All rights reserved.
Research Methodologies and Practical Applications in Psychoneuroimmunology;pp.421-451
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https://doi.org/10.4018/979-8-3693-7432-0.ch019 https://www.scopus.com/pages/publications/105003128885?origin=resultslist