Psychoneuroimmunology and gut microbiota
Gastrointestinal tract harbours a very complex and dynamic community of microorganisms known as the 'gut microbiota'. These microbes are involved in various critical physiological processes, including the digestion of complex biomolecules, synthesis of vitamins, modulation of the immune system, and protection against pathogens. This chapter provides a comprehensive overview of the gut brain axis. The chapter delves into the role of microbial metabolites like short chain fatty acids, tryptophan and bile acids in neuronal and neurotransmitter functioning. Cytokine release and immune system activation can potentially change the gut microbiota composition. The role of psychological stress in reducing beneficial bacteria and increasing pathogenic bacteria composition in the microbiota has been detailed. Psychological stress can lead to these consequences by altering the permeability of the intestinal cells. The effect of compromised permeability on psychological health through altered neurotransmitter activity are discussed. 2025 by IGI Global Scientific Publishing. All rights reserved.
Mayegowda, Shilpa Borehalli; Shah, Mana Ajay; Ray, Karubaki
Research Methodologies and Practical Applications in Psychoneuroimmunology;pp.453-482
Restricted Access; Hardcopy may be available in the library
https://doi.org/10.4018/979-8-3693-7432-0.ch020 https://www.scopus.com/pages/publications/105003250151?origin=resultslist
Mayegowda S.B., Christ University, India; Shah M.A., Christ University, India; Ray K., Christ University, India